A computer analysis of factors influencing the cerebello-thalamo-cortical signals

Samuel H.H. Chan*, Howard J. Wing

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

A computer program developed from a model on the cerebello-thalamo-cortical pathway has been used to analyze the effects of varying three mathematical constants, corresponding to latency (L), effective time range of influence (E), and range of projection (R2), on this circuitry, using correlation coefficient (c.c.) between computer-generated and experimentally-recorded cortical responses to the same cerebello-thalamic signal at corresponding time units as the index. Optimal values for L, E, and R2, which together produce a peak c.c. between theoretical and experimental cortical field potentials, have been obtained, after sampling 1600 combinations of values of these factors. Optimization of these values have been suggested to represent the requirement of precision timing for the arrival of diverse cerebello-thalamic inputs, to concertly activate a set of efferent zones in the motor cortex, in the production of well-coordinated movements.

Original languageEnglish
Pages (from-to)481-489
Number of pages9
JournalComputers and Biomedical Research
Volume11
Issue number5
DOIs
StatePublished - 10 1978
Externally publishedYes

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