TY - JOUR
T1 - A computer analysis of factors influencing the cerebello-thalamo-cortical signals
AU - Chan, Samuel H.H.
AU - Wing, Howard J.
PY - 1978/10
Y1 - 1978/10
N2 - A computer program developed from a model on the cerebello-thalamo-cortical pathway has been used to analyze the effects of varying three mathematical constants, corresponding to latency (L), effective time range of influence (E), and range of projection (R2), on this circuitry, using correlation coefficient (c.c.) between computer-generated and experimentally-recorded cortical responses to the same cerebello-thalamic signal at corresponding time units as the index. Optimal values for L, E, and R2, which together produce a peak c.c. between theoretical and experimental cortical field potentials, have been obtained, after sampling 1600 combinations of values of these factors. Optimization of these values have been suggested to represent the requirement of precision timing for the arrival of diverse cerebello-thalamic inputs, to concertly activate a set of efferent zones in the motor cortex, in the production of well-coordinated movements.
AB - A computer program developed from a model on the cerebello-thalamo-cortical pathway has been used to analyze the effects of varying three mathematical constants, corresponding to latency (L), effective time range of influence (E), and range of projection (R2), on this circuitry, using correlation coefficient (c.c.) between computer-generated and experimentally-recorded cortical responses to the same cerebello-thalamic signal at corresponding time units as the index. Optimal values for L, E, and R2, which together produce a peak c.c. between theoretical and experimental cortical field potentials, have been obtained, after sampling 1600 combinations of values of these factors. Optimization of these values have been suggested to represent the requirement of precision timing for the arrival of diverse cerebello-thalamic inputs, to concertly activate a set of efferent zones in the motor cortex, in the production of well-coordinated movements.
UR - http://www.scopus.com/inward/record.url?scp=0018142727&partnerID=8YFLogxK
U2 - 10.1016/0010-4809(78)90005-8
DO - 10.1016/0010-4809(78)90005-8
M3 - 文章
C2 - 738027
AN - SCOPUS:0018142727
SN - 0010-4809
VL - 11
SP - 481
EP - 489
JO - Computers and Biomedical Research
JF - Computers and Biomedical Research
IS - 5
ER -