A computer analysis of factors influencing the cerebello-thalamo-cortical signals

A computer program developed from a model on the cerebello-thalamo-cortical pathway has been used to analyze the effects of varying three mathematical constants, corresponding to latency (L), effective time range of influence (E), and range of projection (R²), on this circuitry, using correlation coefficient (c.c.) between computer-generated and experimentally-recorded cortical responses to the same cerebello-thalamic signal at corresponding time units as the index. Optimal values for L, E, and R², which together produce a peak c.c. between theoretical and experimental cortical field potentials, have been obtained, after sampling 1600 combinations of values of these factors. Optimization of these values have been suggested to represent the requirement of precision timing for the arrival of diverse cerebello-thalamic inputs, to concertly activate a set of efferent zones in the motor cortex, in the production of well-coordinated movements.