A computer program for the analysis of cerebello-thalamo-cortical signals

A computer program has been developed to analyze the neuronal signals in the cerebello-thalamo-cortical pathway. The mathematical constants in an equation capable of approximating cortical responses were systematically altered by the program in the calculation of theoretical cortical values. Using the correlation coefficient between the computer-generated and the experimentally produced cortical responses to the same thalamic signal, as evoked by a cerebellar stimulation, the effects of varying these constants can be determined. As these constants bear physiological meanings, the connections between the cerebellum, thalamus, and motor cortex, believed to play an important role in voluntary movements, can be studied in simulated, normal, and abnormal situations by introducing different values of these parameters into the program.