A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang; M. Vijaya Bhaskar Reddy; Ping Chung Kuo; Chieh Hung Huang; Hung Cheng Shih; E. Jian Lee; Mei Lin Yang; Yann Lii Leu; Tian Shung Wu

doi:10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang, M. Vijaya Bhaskar Reddy, Ping Chung Kuo, Chieh Hung Huang, Hung Cheng Shih, E. Jian Lee, Mei Lin Yang, Yann Lii Leu, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

37 Scopus citations

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Original language	English
Pages (from-to)	371-378
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	48
DOIs	https://doi.org/10.1016/j.ejmech.2011.12.008
State	Published - 02 2012

Keywords

Anti-Inflammatory
COX-2
Macrophages
Viscolin
iNOS
λ-Carrageenin

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10.1016/j.ejmech.2011.12.008

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Huang, G. J., Bhaskar Reddy, M. V., Kuo, P. C., Huang, C. H., Shih, H. C., Lee, E. J., Yang, M. L., Leu, Y. L., & Wu, T. S. (2012). A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. European Journal of Medicinal Chemistry, 48, 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

@article{a9c0a115ca6f4728907924516d211c5d,

title = "A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions",

abstract = "In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.",

keywords = "Anti-Inflammatory, COX-2, Macrophages, Viscolin, iNOS, λ-Carrageenin",

author = "Huang, {Guan Jhong} and {Bhaskar Reddy}, {M. Vijaya} and Kuo, {Ping Chung} and Huang, {Chieh Hung} and Shih, {Hung Cheng} and Lee, {E. Jian} and Yang, {Mei Lin} and Leu, {Yann Lii} and Wu, {Tian Shung}",

year = "2012",

month = feb,

doi = "10.1016/j.ejmech.2011.12.008",

language = "英语",

volume = "48",

pages = "371--378",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

}

Huang, GJ, Bhaskar Reddy, MV, Kuo, PC, Huang, CH, Shih, HC, Lee, EJ, Yang, ML, Leu, YL & Wu, TS 2012, 'A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions', European Journal of Medicinal Chemistry, vol. 48, pp. 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. / Huang, Guan Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping Chung et al.
In: European Journal of Medicinal Chemistry, Vol. 48, 02.2012, p. 371-378.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

AU - Huang, Guan Jhong

AU - Bhaskar Reddy, M. Vijaya

AU - Kuo, Ping Chung

AU - Huang, Chieh Hung

AU - Shih, Hung Cheng

AU - Lee, E. Jian

AU - Yang, Mei Lin

AU - Leu, Yann Lii

AU - Wu, Tian Shung

PY - 2012/2

Y1 - 2012/2

N2 - In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

AB - In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

KW - Anti-Inflammatory

KW - COX-2

KW - Macrophages

KW - Viscolin

KW - iNOS

KW - λ-Carrageenin

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U2 - 10.1016/j.ejmech.2011.12.008

DO - 10.1016/j.ejmech.2011.12.008

M3 - 文章

C2 - 22197135

AN - SCOPUS:84855993095

SN - 0223-5234

VL - 48

SP - 371

EP - 378

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

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Keywords

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