A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang; M. Vijaya Bhaskar Reddy; Ping Chung Kuo; Chieh Hung Huang; Hung Cheng Shih; E. Jian Lee; Mei Lin Yang; Yann Lii Leu; Tian Shung Wu

doi:10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang
, M. Vijaya Bhaskar Reddy
, Ping Chung Kuo
, Chieh Hung Huang
, Hung Cheng Shih
, E. Jian Lee
, Mei Lin Yang
, Yann Lii Leu
, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

38 Scopus citations

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Original language	English
Pages (from-to)	371-378
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	48
DOIs	https://doi.org/10.1016/j.ejmech.2011.12.008
State	Published - 02 2012

Keywords

Anti-Inflammatory
COX-2
Macrophages
Viscolin
iNOS
λ-Carrageenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2011.12.008

Cite this

Huang, G. J., Bhaskar Reddy, M. V., Kuo, P. C., Huang, C. H., Shih, H. C., Lee, E. J., Yang, M. L., Leu, Y. L., & Wu, T. S. (2012). A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. European Journal of Medicinal Chemistry, 48, 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

@article{a9c0a115ca6f4728907924516d211c5d,

title = "A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions",

abstract = "In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.",

keywords = "Anti-Inflammatory, COX-2, Macrophages, Viscolin, iNOS, λ-Carrageenin",

author = "Huang, \{Guan Jhong\} and \{Bhaskar Reddy\}, \{M. Vijaya\} and Kuo, \{Ping Chung\} and Huang, \{Chieh Hung\} and Shih, \{Hung Cheng\} and Lee, \{E. Jian\} and Yang, \{Mei Lin\} and Leu, \{Yann Lii\} and Wu, \{Tian Shung\}",

year = "2012",

month = feb,

doi = "10.1016/j.ejmech.2011.12.008",

language = "英语",

volume = "48",

pages = "371--378",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

}

Huang, GJ, Bhaskar Reddy, MV, Kuo, PC, Huang, CH, Shih, HC, Lee, EJ, Yang, ML, Leu, YL & Wu, TS 2012, 'A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions', European Journal of Medicinal Chemistry, vol. 48, pp. 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. / Huang, Guan Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping Chung et al.
In: European Journal of Medicinal Chemistry, Vol. 48, 02.2012, p. 371-378.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

AU - Huang, Guan Jhong

AU - Bhaskar Reddy, M. Vijaya

AU - Kuo, Ping Chung

AU - Huang, Chieh Hung

AU - Shih, Hung Cheng

AU - Lee, E. Jian

AU - Yang, Mei Lin

AU - Leu, Yann Lii

AU - Wu, Tian Shung

PY - 2012/2

Y1 - 2012/2

N2 - In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

AB - In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

KW - Anti-Inflammatory

KW - COX-2

KW - Macrophages

KW - Viscolin

KW - iNOS

KW - λ-Carrageenin

UR - https://www.scopus.com/pages/publications/84855993095

U2 - 10.1016/j.ejmech.2011.12.008

DO - 10.1016/j.ejmech.2011.12.008

M3 - 文章

C2 - 22197135

AN - SCOPUS:84855993095

SN - 0223-5234

VL - 48

SP - 371

EP - 378

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Abstract

Keywords

UN SDGs

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