A controlled-release drug delivery system on a chip using electrolysis

Pen Li Huang; Po Hung Kuo; Yu Jie Huang; Hsin Hung Liao; Yao Joe Joseph Yang; Tao Wang; Yao Hung Wang; Shey Shi Lu

doi:10.1109/TIE.2011.2160135

A controlled-release drug delivery system on a chip using electrolysis

Pen Li Huang^*
, Po Hung Kuo
, Yu Jie Huang
, Hsin Hung Liao
, Yao Joe Joseph Yang
, Tao Wang
, Yao Hung Wang
, Shey Shi Lu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-μm CMOS technology followed by post-IC processing. The total size is 2.48 mm², and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC.

Original language	English
Article number	5898406
Pages (from-to)	1578-1587
Number of pages	10
Journal	IEEE Transactions on Industrial Electronics
Volume	59
Issue number	3
DOIs	https://doi.org/10.1109/TIE.2011.2160135
State	Published - 03 2012
Externally published	Yes

Keywords

Biomedical
CMOS integrated circuit (IC)
drug delivery
system-on-a-chip

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TIE.2011.2160135

Cite this

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title = "A controlled-release drug delivery system on a chip using electrolysis",

abstract = "A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-μm CMOS technology followed by post-IC processing. The total size is 2.48 mm2, and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC.",

keywords = "Biomedical, CMOS integrated circuit (IC), drug delivery, system-on-a-chip",

author = "Huang, \{Pen Li\} and Kuo, \{Po Hung\} and Huang, \{Yu Jie\} and Liao, \{Hsin Hung\} and Yang, \{Yao Joe Joseph\} and Tao Wang and Wang, \{Yao Hung\} and Lu, \{Shey Shi\}",

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doi = "10.1109/TIE.2011.2160135",

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AU - Huang, Pen Li

AU - Kuo, Po Hung

AU - Huang, Yu Jie

AU - Liao, Hsin Hung

AU - Yang, Yao Joe Joseph

AU - Wang, Tao

AU - Wang, Yao Hung

AU - Lu, Shey Shi

PY - 2012/3

Y1 - 2012/3

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AB - A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-μm CMOS technology followed by post-IC processing. The total size is 2.48 mm2, and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC.

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KW - CMOS integrated circuit (IC)

KW - drug delivery

KW - system-on-a-chip

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M3 - 文章

AN - SCOPUS:80155208114

SN - 0278-0046

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JF - IEEE Transactions on Industrial Electronics

IS - 3

M1 - 5898406

ER -

A controlled-release drug delivery system on a chip using electrolysis

Abstract

Keywords

UN SDGs

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