A histologic and immunohistochemical analysis of defective vaginal healing after continence taping procedures: A prospective case-controlled pilot study

Alex C. Wang, Li Yu Lee, Cheng Tao Lin, Jim Ray Chen

Research output: Contribution to journalJournal Article peer-review

49 Scopus citations

Abstract

The purpose of this study was to investigate vaginal rejection of polypropylene mesh after continence taping procedures. Of 700 women who had undergone the procedures, 17 women with sling erosion and 7 women with voiding difficulty or symptomatic vagina prolapse (control subjects) underwent histopathologic evaluation and immunohistochemistry. Seven women whose condition was not responding to conservative treatment and debridements had the exposed suburethral tape excised, which revealed predominant foreign body reaction and fragmented mesh that was surrounded by histiocytes and dense fibrosis. Immunohistochemical analysis revealed that the cell density percentage of CD20+ cells was statistically significantly greater in the persistent defective healing group than in either the single-debridement or control group (P =. 014 and P =. 014, respectively). We found statistically significant differences between the persistent defective healing and single-debridement groups and between the former and control groups in the ratios of T and B cells (P =. 035 and P =. 022, respectively). The rate of defective vaginal healing after the procedures was 2.4%. Removal of the prosthesis and surrounding tissue at various times for the 7 women resulted in histopathologic findings that suggested a immunologic reaction. The rate of persistent defective healing of the vagina was 1%.

Original languageEnglish
Pages (from-to)1868-1874
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume191
Issue number6
DOIs
StatePublished - 12 2004
Externally publishedYes

Keywords

  • Continence taping procedure
  • Defective vaginal healing
  • Hematoxylin-eosin stain
  • Immunohistochemical study
  • Polypropylene mesh

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