A hypothetical protein of Streptococcus mutans is critical for biofilm formation

Thomas A. Brown; Sang Joon Ahn; Roslyn N. Frank; Yi Ywan M. Chen; José A. Lemos; Robert A. Burne

doi:10.1128/IAI.73.5.3147-3151.2005

A hypothetical protein of Streptococcus mutans is critical for biofilm formation

Thomas A. Brown, Sang Joon Ahn, Roslyn N. Frank, Yi Ywan M. Chen, José A. Lemos, Robert A. Burne^*

^*Corresponding author for this work

University of Florida

Research output: Contribution to journal › Journal Article › peer-review

38 Scopus citations

Abstract

Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.

Original language	English
Pages (from-to)	3147-3151
Number of pages	5
Journal	Infection and Immunity
Volume	73
Issue number	5
DOIs	https://doi.org/10.1128/IAI.73.5.3147-3151.2005
State	Published - 05 2005
Externally published	Yes

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10.1128/IAI.73.5.3147-3151.2005

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title = "A hypothetical protein of Streptococcus mutans is critical for biofilm formation",

abstract = "Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.",

author = "Brown, \{Thomas A.\} and Ahn, \{Sang Joon\} and Frank, \{Roslyn N.\} and Chen, \{Yi Ywan M.\} and Lemos, \{Jos{\'e} A.\} and Burne, \{Robert A.\}",

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doi = "10.1128/IAI.73.5.3147-3151.2005",

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AU - Brown, Thomas A.

AU - Ahn, Sang Joon

AU - Frank, Roslyn N.

AU - Chen, Yi Ywan M.

AU - Lemos, José A.

AU - Burne, Robert A.

PY - 2005/5

Y1 - 2005/5

N2 - Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.

AB - Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.

UR - https://www.scopus.com/pages/publications/17644388851

U2 - 10.1128/IAI.73.5.3147-3151.2005

DO - 10.1128/IAI.73.5.3147-3151.2005

M3 - 文章

C2 - 15845523

AN - SCOPUS:17644388851

SN - 0019-9567

VL - 73

SP - 3147

EP - 3151

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

A hypothetical protein of Streptococcus mutans is critical for biofilm formation

Abstract

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