A multicenter retrospective analysis of patients with salivary gland carcinoma treated with postoperative radiotherapy alone or chemoradiotherapy: PORT or POCRT for salivary gland cancer

Rodney Cheng En Hsieh, Yung Chih Chou, Chia Yen Hung, Li Yu Lee, Bhanu Prasad Venkatesulu, Shiang Fu Huang, Chun Ta Liao, Nai Ming Cheng, Hung Ming Wang, Chiao En Wu, Chung Jan Kang, Miao-fen Chen, Yu-Fan Cheng, Kun Yun Yeh, Cheng-Hsu Wang, Wen-Chi Chou*, Chien Yu Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

Background: The aim of this study was to interrogate if the use of postoperative chemoradiotherapy (POCRT) correlated with superior oncological outcomes for certain subgroups of patients with high-risk salivary gland carcinoma (SGC), compared with postoperative radiotherapy (PORT) alone. Methods: This multicenter retrospective study included 411 patients with surgically resected SGC who underwent PORT (n = 263) or POCRT (n = 148) between 2000 and 2015. Possible correlations of clinical parameters with outcomes were examined using the Kaplan-Meier analysis and Cox proportional-hazards regression model. Results: The median follow-up of survivors is 10.9 years. For the entire cohort, adding concurrent chemotherapy to PORT was not associated with OS, PFS, or LRC improvement. However, patients with nodal metastasis who underwent POCRT had significantly higher 10-year OS (46.2% vs. 18.2%, P = 0.009) and PFS (38.7% vs. 10.0%, P = 0.009) rates than those treated with PORT alone. The presence of postoperative macroscopic residual tumor (R2 resection) was identified as an independent prognosticator for inferior OS (P = 0.032), PFS (P = 0.001), and LRC (P = 0.007). Importantly, POCRT significantly correlated with higher 10-year LRC rates in patients with R2 resection (74.2% vs. 40.7%, P = 0.034) or adenoid cystic carcinoma (AdCC, 97.6% vs. 83.6%, P = 0.039). On multivariate analyses, the use of POCRT significantly predicted superior OS (P = 0.037) and PFS (P = 0.013) for node-positive patients and LRC for patients with R2 resection (P = 0.041) or AdCC (P = 0.005). Conclusions: For surgically resected SGC, POCRT was associated with improved long-term OS and PFS for patients with nodal metastasis and superior LRC for patients with R2 resection or AdCC.

Original languageEnglish
Article number109891
Pages (from-to)109891
JournalRadiotherapy and Oncology
Volume188
DOIs
StatePublished - 11 2023

Bibliographical note

Copyright © 2023 Elsevier B.V. All rights reserved.

Keywords

  • Adenoid cystic carcinoma
  • Concurrent chemotherapy
  • Nodal metastasis
  • Postoperative gross residual tumor
  • R2 resection
  • Salivary gland cancer

Fingerprint

Dive into the research topics of 'A multicenter retrospective analysis of patients with salivary gland carcinoma treated with postoperative radiotherapy alone or chemoradiotherapy: PORT or POCRT for salivary gland cancer'. Together they form a unique fingerprint.

Cite this