A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound

Hsin Yang Huang; Hao Li Liu; Po Hung Hsu; Chih Sheng Chiang; Chih Hung Tsai; Huei Shang Chi; San Yuan Chen; You Yin Chen

doi:10.1002/adma.201403889

A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound

Hsin Yang Huang
, Hao Li Liu
, Po Hung Hsu
, Chih Sheng Chiang
, Chih Hung Tsai
, Huei Shang Chi
, San Yuan Chen^*
, You Yin Chen

^*Corresponding author for this work

Department of Electrical Engineering

Research output: Contribution to journal › Journal Article › peer-review

99 Scopus citations

Abstract

(Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

Original language	English
Pages (from-to)	655-661
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	4
DOIs	https://doi.org/10.1002/adma.201403889
State	Published - 27 01 2015

Bibliographical note

Publisher Copyright:
© Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

Brainâ-blood barrier
Focused ultrasound
Magnetic guidance
Nanobubbles

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10.1002/adma.201403889

Cite this

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title = "A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound",

abstract = "(Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.",

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doi = "10.1002/adma.201403889",

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AU - Huang, Hsin Yang

AU - Liu, Hao Li

AU - Hsu, Po Hung

AU - Chiang, Chih Sheng

AU - Tsai, Chih Hung

AU - Chi, Huei Shang

AU - Chen, San Yuan

AU - Chen, You Yin

N1 - Publisher Copyright: © Wiley-VCH Verlag GmbH & Co. KGaA.

PY - 2015/1/27

Y1 - 2015/1/27

N2 - (Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

AB - (Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

KW - Brainâ-blood barrier

KW - Focused ultrasound

KW - Magnetic guidance

KW - Nanobubbles

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DO - 10.1002/adma.201403889

M3 - 文章

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SP - 655

EP - 661

JO - Advanced Materials

JF - Advanced Materials

IS - 4

ER -

A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound

Abstract

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Keywords

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