A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

Hsin Shih Wang; Bi Hwa Cheng; Hsien Ming Wu; Chih Feng Yen; Chun Ting Liu; Angel Chao; Tzu Hao Wang

doi:10.1016/j.fertnstert.2010.07.1092

A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

Hsin Shih Wang, Bi Hwa Cheng, Hsien Ming Wu, Chih Feng Yen, Chun Ting Liu, Angel Chao, Tzu Hao Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680 ^Ser/Ser) and GA genotype (680^Ser/Asn) were associated with a significantly lower risk of endometriosis.

Original language	English
Pages (from-to)	455-457
Number of pages	3
Journal	Fertility and Sterility
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.07.1092
State	Published - 01 2011

Keywords

Endometriosis
matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)
single nucleotide polymorphism (SNP)

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10.1016/j.fertnstert.2010.07.1092

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title = "A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis",

abstract = "Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680 Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.",

keywords = "Endometriosis, matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS), single nucleotide polymorphism (SNP)",

author = "Wang, {Hsin Shih} and Cheng, {Bi Hwa} and Wu, {Hsien Ming} and Yen, {Chih Feng} and Liu, {Chun Ting} and Angel Chao and Wang, {Tzu Hao}",

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T1 - A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

AU - Wang, Hsin Shih

AU - Cheng, Bi Hwa

AU - Wu, Hsien Ming

AU - Yen, Chih Feng

AU - Liu, Chun Ting

AU - Chao, Angel

AU - Wang, Tzu Hao

PY - 2011/1

Y1 - 2011/1

N2 - Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680 Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.

AB - Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680 Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.

KW - Endometriosis

KW - matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)

KW - single nucleotide polymorphism (SNP)

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M3 - 文章

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AN - SCOPUS:78650419887

SN - 0015-0282

VL - 95

SP - 455

EP - 457

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

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