A National Case-Crossover Study on the Risk of Kidney Injury Requiring Dialysis after Sepsis

Chung Shun Wong, Tzu Ting Chen, Andrei R. Akhmetzhanov, Ping Jen Hu, Mai Szu Wu, Mei Yi Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Background: Patients with sepsis-associated acute kidney injury (AKI) are at risk of kidney damage, potentially necessitating acute temporary or chronic dialysis. Our study aims to estimate the odds ratio (OR) of preceding sepsis among patients requiring their first dialysis. Methods: A nationwide population-based case-only study was conducted using claims records from the National Health insurance database of Taiwan. All patients over 20 years of age who underwent their first dialysis between 2004 and 2016 were included in the study. The six months prior to their first dialysis served as a self-control period. Results: The study included 147,201 patients who required acute temporary and 75,031 patients who required chronic dialysis. The odds ratios for patients needing acute temporary dialysis after 1, 2, 3, and 4 weeks of exposure periods were 15.8, 10.7, 9.2, and 8.4, respectively. The ORs for patients requiring chronic dialysis were 7.0, 4.1, 4.2, and 3.7, respectively. Conclusions: Our findings indicate that sepsis was substantially associated with an increased risk of renal failure. The risk was highest during the first week following sepsis for both acute temporary and chronic dialysis cases.

Original languageEnglish
Article number4950
JournalJournal of Clinical Medicine
Volume12
Issue number15
DOIs
StatePublished - 27 07 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • acute kidney injury
  • acute temporary dialysis
  • chronic dialysis
  • chronic kidney disease
  • sepsis

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