TY - JOUR
T1 - A new 2H-pyran-2-one derivative and anti-inflammatory constituents of alpinia zerumbet
AU - Chen, Jih Jung
AU - Liao, Hsiang Ruei
AU - Chen, Keh Shaw
AU - Cheng, Ming Jen
AU - Shu, Chih Wen
AU - Sung, Ping Jyun
AU - Lim, Yun Ping
AU - Wang, Tai Chi
AU - Kuo, Wen Lung
N1 - Publisher Copyright:
© 2017 Springer Science+Business Media New York.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent inhibition, with IC50 values of 3.18 1.13 and 1.17 0.13 µg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2·-) generation.
AB - A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent inhibition, with IC50 values of 3.18 1.13 and 1.17 0.13 µg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2·-) generation.
KW - 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one
KW - Alpinia zerumbet
KW - Zingiberaceae
UR - https://www.scopus.com/pages/publications/85013377768
U2 - 10.1007/s10600-017-1906-6
DO - 10.1007/s10600-017-1906-6
M3 - 文章
AN - SCOPUS:85013377768
SN - 0009-3130
VL - 53
SP - 40
EP - 43
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
IS - 1
ER -