A new benzenoid and anti-inflammatory constituent of capparis acutifolia

Jih Jung Chen; Wen Lung Kuo; Hsiang Ruei Liao; Yueh Hsiung Kuo; Ih Sheng Chen; Chih Wen Shu; Ping Jyun Sung; Yun Ping Lim; Tai Chi Wang; Ming Jen Cheng; Rong Xu

doi:10.1007/s10600-017-1901-y

A new benzenoid and anti-inflammatory constituent of capparis acutifolia

Jih Jung Chen^*, Wen Lung Kuo, Hsiang Ruei Liao, Yueh Hsiung Kuo, Ih Sheng Chen, Chih Wen Shu, Ping Jyun Sung, Yun Ping Lim, Tai Chi Wang, Ming Jen Cheng, Rong Xu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

A new benzenoid, propyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (1), has been isolated from the stems of Capparis acutifolia, together with five known compounds, rutin (2), 3β-hydroxystigmast-5-en-7-one (3), 6 -hydroxystigmast-4-en-3-one (4), sitosterol trans-ferulate (5), and sitosterol cis-ferulate (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Rutin (2) exhibited potent inhibition, with IC₅₀ value of 1.26±0.15µg/mL, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O₂·-) generation.

Original language	English
Pages (from-to)	21-23
Number of pages	3
Journal	Chemistry of Natural Compounds
Volume	53
Issue number	1
DOIs	https://doi.org/10.1007/s10600-017-1901-y
State	Published - 01 01 2017
Externally published	Yes

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Publisher Copyright:
© 2017 Springer Science+Business Media New York.

Keywords

3]dioxole-5-carboxylate
Anti-inflammatory activity
Benzenoid
Capparaceae
Capparis acutifolia
Propyl 7-methoxybenzo[d][1

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10.1007/s10600-017-1901-y

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title = "A new benzenoid and anti-inflammatory constituent of capparis acutifolia",

abstract = "A new benzenoid, propyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (1), has been isolated from the stems of Capparis acutifolia, together with five known compounds, rutin (2), 3β-hydroxystigmast-5-en-7-one (3), 6 -hydroxystigmast-4-en-3-one (4), sitosterol trans-ferulate (5), and sitosterol cis-ferulate (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Rutin (2) exhibited potent inhibition, with IC50 value of 1.26±0.15µg/mL, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2·-) generation.",

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doi = "10.1007/s10600-017-1901-y",

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AU - Chen, Jih Jung

AU - Kuo, Wen Lung

AU - Liao, Hsiang Ruei

AU - Kuo, Yueh Hsiung

AU - Chen, Ih Sheng

AU - Shu, Chih Wen

AU - Sung, Ping Jyun

AU - Lim, Yun Ping

AU - Wang, Tai Chi

AU - Cheng, Ming Jen

AU - Xu, Rong

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N2 - A new benzenoid, propyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (1), has been isolated from the stems of Capparis acutifolia, together with five known compounds, rutin (2), 3β-hydroxystigmast-5-en-7-one (3), 6 -hydroxystigmast-4-en-3-one (4), sitosterol trans-ferulate (5), and sitosterol cis-ferulate (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Rutin (2) exhibited potent inhibition, with IC50 value of 1.26±0.15µg/mL, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2·-) generation.

AB - A new benzenoid, propyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (1), has been isolated from the stems of Capparis acutifolia, together with five known compounds, rutin (2), 3β-hydroxystigmast-5-en-7-one (3), 6 -hydroxystigmast-4-en-3-one (4), sitosterol trans-ferulate (5), and sitosterol cis-ferulate (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Rutin (2) exhibited potent inhibition, with IC50 value of 1.26±0.15µg/mL, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2·-) generation.

KW - 3]dioxole-5-carboxylate

KW - Anti-inflammatory activity

KW - Benzenoid

KW - Capparaceae

KW - Capparis acutifolia

KW - Propyl 7-methoxybenzo[d][1

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DO - 10.1007/s10600-017-1901-y

M3 - 文章

AN - SCOPUS:85013035484

SN - 0009-3130

VL - 53

SP - 21

EP - 23

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

IS - 1

ER -

A new benzenoid and anti-inflammatory constituent of capparis acutifolia

Abstract

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