A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

Chia Wei Ting; Tsong Long Hwang; Ih Sheng Chen; Ming Hong Yen; Jih Jung Chen

doi:10.1002/cbdv.201100006

A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

Chia Wei Ting
, Tsong Long Hwang
, Ih Sheng Chen
, Ming Hong Yen^*
, Jih Jung Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Kaohsiung Medical University
Tajen University

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC ₅₀ values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

Original language	English
Pages (from-to)	99-105
Number of pages	7
Journal	Chemistry and Biodiversity
Volume	9
Issue number	1
DOIs	https://doi.org/10.1002/cbdv.201100006
State	Published - 01 2012

Keywords

Garcimultiflorone D
Garcinia multiflora
Inhibitors
Neutrophil pro-inflammatory responses
Phloroglucinol derivatives

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10.1002/cbdv.201100006

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abstract = "A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC 50 values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.",

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author = "Ting, \{Chia Wei\} and Hwang, \{Tsong Long\} and Chen, \{Ih Sheng\} and Yen, \{Ming Hong\} and Chen, \{Jih Jung\}",

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AU - Chen, Ih Sheng

AU - Yen, Ming Hong

AU - Chen, Jih Jung

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AB - A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC 50 values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

KW - Garcimultiflorone D

KW - Garcinia multiflora

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KW - Neutrophil pro-inflammatory responses

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A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

Abstract

Keywords

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