A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils

Jih Jung Chen; Yu Ting Luo; Chang Hui Liao; Ih Sheng Chen; Chih Chuang Liaw

doi:10.1002/cbdv.200800118

A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils

Jih Jung Chen^*
, Yu Ting Luo
, Chang Hui Liao
, Ih Sheng Chen
, Chih Chuang Liaw

^*Corresponding author for this work

School of Traditional Chinese Medicine

Tajen University
Kaohsiung Medical University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and massspectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O₂^.-) production by human neutrophils with IC₅₀ values of 18.7±4.4 and 17.0±6.8 μM, resp.

Original language	English
Pages (from-to)	774-778
Number of pages	5
Journal	Chemistry and Biodiversity
Volume	6
Issue number	5
DOIs	https://doi.org/10.1002/cbdv.200800118
State	Published - 05 2009

Keywords

LEUKOCYTES
PHYTOALEXINS
SAPWOOD

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title = "A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils",

abstract = "A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and massspectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O2.-) production by human neutrophils with IC50 values of 18.7±4.4 and 17.0±6.8 μM, resp.",

keywords = "LEUKOCYTES, PHYTOALEXINS, SAPWOOD",

author = "Chen, \{Jih Jung\} and Luo, \{Yu Ting\} and Liao, \{Chang Hui\} and Chen, \{Ih Sheng\} and Liaw, \{Chih Chuang\}",

year = "2009",

month = may,

doi = "10.1002/cbdv.200800118",

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T1 - A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils

AU - Chen, Jih Jung

AU - Luo, Yu Ting

AU - Liao, Chang Hui

AU - Chen, Ih Sheng

AU - Liaw, Chih Chuang

PY - 2009/5

Y1 - 2009/5

N2 - A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and massspectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O2.-) production by human neutrophils with IC50 values of 18.7±4.4 and 17.0±6.8 μM, resp.

AB - A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and massspectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O2.-) production by human neutrophils with IC50 values of 18.7±4.4 and 17.0±6.8 μM, resp.

KW - LEUKOCYTES

KW - PHYTOALEXINS

KW - SAPWOOD

UR - https://www.scopus.com/pages/publications/67649317282

U2 - 10.1002/cbdv.200800118

DO - 10.1002/cbdv.200800118

M3 - 文章

C2 - 19479843

AN - SCOPUS:67649317282

SN - 1612-1872

VL - 6

SP - 774

EP - 778

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 5

ER -

A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils

Abstract

Keywords

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