A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam; Shu Duan Jian; Tsong Long Hwang; Po Jen Chen; Hsin Yi Hung; Ping Chung Kuo; Tian Shung Wu

doi:10.1080/14786419.2019.1611809

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam, Shu Duan Jian, Tsong Long Hwang, Po Jen Chen, Hsin Yi Hung, Ping Chung Kuo^*, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

Abstract

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Natural Product Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1080/14786419.2019.1611809
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Menispermaceae
anti-inflammatory
elastase release
superoxide anion generation

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10.1080/14786419.2019.1611809

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abstract = "A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.",

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AU - Lam, Sio Hong

AU - Jian, Shu Duan

AU - Hwang, Tsong Long

AU - Chen, Po Jen

AU - Hung, Hsin Yi

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2021

Y1 - 2021

N2 - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

AB - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

KW - Menispermaceae

KW - anti-inflammatory

KW - elastase release

KW - superoxide anion generation

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AN - SCOPUS:85098629704

SN - 1478-6419

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SP - 17

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JO - Natural Product Research

JF - Natural Product Research

IS - 1

ER -

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Abstract

Bibliographical note

Keywords

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