A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam; Shu Duan Jian; Tsong Long Hwang; Po Jen Chen; Hsin Yi Hung; Ping Chung Kuo; Tian Shung Wu

doi:10.1080/14786419.2019.1611809

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam
, Shu Duan Jian
, Tsong Long Hwang
, Po Jen Chen
, Hsin Yi Hung
, Ping Chung Kuo^*
, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Natural Product Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1080/14786419.2019.1611809
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Menispermaceae
anti-inflammatory
elastase release
superoxide anion generation

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10.1080/14786419.2019.1611809

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title = "A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata",

abstract = "A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.",

keywords = "Menispermaceae, anti-inflammatory, elastase release, superoxide anion generation",

author = "Lam, \{Sio Hong\} and Jian, \{Shu Duan\} and Hwang, \{Tsong Long\} and Chen, \{Po Jen\} and Hung, \{Hsin Yi\} and Kuo, \{Ping Chung\} and Wu, \{Tian Shung\}",

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year = "2021",

doi = "10.1080/14786419.2019.1611809",

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T1 - A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

AU - Lam, Sio Hong

AU - Jian, Shu Duan

AU - Hwang, Tsong Long

AU - Chen, Po Jen

AU - Hung, Hsin Yi

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2021

Y1 - 2021

N2 - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

AB - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

KW - Menispermaceae

KW - anti-inflammatory

KW - elastase release

KW - superoxide anion generation

UR - https://www.scopus.com/pages/publications/85098629704

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DO - 10.1080/14786419.2019.1611809

M3 - 文章

C2 - 31135226

AN - SCOPUS:85098629704

SN - 1478-6419

VL - 35

SP - 17

EP - 24

JO - Natural Product Research

JF - Natural Product Research

IS - 1

ER -

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Abstract

Bibliographical note

Keywords

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