TY - JOUR
T1 - A new ferulic acid ester, a new ellagic acid derivative, and other constituents from Pachycentria formosana
T2 - Effects on neutrophil pro-inflammatory responses
AU - Cho, Jui Ying
AU - Lee, Tzong Huei
AU - Hwang, Tsong Long
AU - Yang, Sheng Zehn
AU - Chen, Ih Sheng
AU - Chou, Tsung Hsien
AU - Sung, Ping Jyun
AU - Chen, Jih Jung
PY - 2011/9
Y1 - 2011/9
N2 - A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4:3′,4′-bis(O,O- methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC 50 values ≤21.8μM) of O 2 ·- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl] ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.6μM.
AB - A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4:3′,4′-bis(O,O- methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC 50 values ≤21.8μM) of O 2 ·- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl] ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.6μM.
KW - Ellagic acid
KW - Ferulic acid ester
KW - Neutrophil pro-inflammatory responses
KW - Pachycentria formosana
UR - http://www.scopus.com/inward/record.url?scp=80052909518&partnerID=8YFLogxK
U2 - 10.1002/cbdv.201000228
DO - 10.1002/cbdv.201000228
M3 - 文章
C2 - 21922659
AN - SCOPUS:80052909518
SN - 1612-1872
VL - 8
SP - 1709
EP - 1716
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 9
ER -