A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis

Jin Jung Chen; Yu Ting Luo; Tsong Long Hwang; Ping Jyun Sung; Tai Chi Wang; Ih Sheng Chen

doi:10.1002/cbdv.200890122

A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis

Jin Jung Chen^*, Yu Ting Luo, Tsong Long Hwang, Ping Jyun Sung, Tai Chi Wang, Ih Sheng Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC₅₀<5.5 μg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.

Original language	English
Pages (from-to)	1345-1352
Number of pages	8
Journal	Chemistry and Biodiversity
Volume	5
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.200890122
State	Published - 2008

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abstract = "A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC50<5.5 μg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.",

author = "Chen, {Jin Jung} and Luo, {Yu Ting} and Hwang, {Tsong Long} and Sung, {Ping Jyun} and Wang, {Tai Chi} and Chen, {Ih Sheng}",

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AU - Chen, Jin Jung

AU - Luo, Yu Ting

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

AU - Wang, Tai Chi

AU - Chen, Ih Sheng

PY - 2008

Y1 - 2008

N2 - A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC50<5.5 μg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.

AB - A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC50<5.5 μg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.

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M3 - 文章

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AN - SCOPUS:52149112102

SN - 1612-1872

VL - 5

SP - 1345

EP - 1352

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 7

ER -

A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis

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