A new quinolone and other constituents from the fruits of Tetradium ruticarpum: Effects on neutrophil pro-inflammatory responses

Tzu Ying Wang; Jin Bin Wu; Tsong Long Hwang; Yueh Hsiung Kuo; Jih Jung Chen

doi:10.1002/cbdv.200900289

A new quinolone and other constituents from the fruits of Tetradium ruticarpum: Effects on neutrophil pro-inflammatory responses

Tzu Ying Wang
, Jin Bin Wu^*
, Tsong Long Hwang
, Yueh Hsiung Kuo
, Jih Jung Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9- dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC ₅₀≤20.9 μM) of O ₂ ^•- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC ₅₀ values ≤14.4 μM.

Original language	English
Pages (from-to)	1828-1834
Number of pages	7
Journal	Chemistry and Biodiversity
Volume	7
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.200900289
State	Published - 07 2010

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title = "A new quinolone and other constituents from the fruits of Tetradium ruticarpum: Effects on neutrophil pro-inflammatory responses",

abstract = "The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9- dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC 50≤20.9 μM) of O 2 •- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC 50 values ≤14.4 μM.",

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AU - Wu, Jin Bin

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AU - Kuo, Yueh Hsiung

AU - Chen, Jih Jung

PY - 2010/7

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N2 - The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9- dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC 50≤20.9 μM) of O 2 •- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC 50 values ≤14.4 μM.

AB - The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9- dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC 50≤20.9 μM) of O 2 •- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC 50 values ≤14.4 μM.

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DO - 10.1002/cbdv.200900289

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AN - SCOPUS:77954712912

SN - 1612-1872

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JO - Chemistry and Biodiversity

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ER -

A new quinolone and other constituents from the fruits of Tetradium ruticarpum: Effects on neutrophil pro-inflammatory responses

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