A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

Jih Jung Chen; Ming Chi Hung; Hsiang Ruei Liao; Yueh Hsiung Kuo; Chih Wen Shu; Ping Jyun Sung; Yun Ping Lim; Wen Lung Kuo; Lin Yang Cheng; Sin Ling Wang; Jui Jen Wu

doi:10.1007/s10600-017-2082-4

A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

Jih Jung Chen^*
, Ming Chi Hung
, Hsiang Ruei Liao
, Yueh Hsiung Kuo
, Chih Wen Shu
, Ping Jyun Sung
, Yun Ping Lim
, Wen Lung Kuo
, Lin Yang Cheng
, Sin Ling Wang
, Jui Jen Wu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC₅₀ values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O₂·^–) generation.

Original language	English
Pages (from-to)	649-652
Number of pages	4
Journal	Chemistry of Natural Compounds
Volume	53
Issue number	4
DOIs	https://doi.org/10.1007/s10600-017-2082-4
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.

Keywords

Garcinia subelliptica
Guttiferae
anti-inflammatory activity
garcisubellone
root
xanthone

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10.1007/s10600-017-2082-4

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@article{a7d13f1f1f784cacb8e842913144c6e4,

title = "A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica",

abstract = "A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation.",

keywords = "Garcinia subelliptica, Guttiferae, anti-inflammatory activity, garcisubellone, root, xanthone",

author = "Chen, \{Jih Jung\} and Hung, \{Ming Chi\} and Liao, \{Hsiang Ruei\} and Kuo, \{Yueh Hsiung\} and Shu, \{Chih Wen\} and Sung, \{Ping Jyun\} and Lim, \{Yun Ping\} and Kuo, \{Wen Lung\} and Cheng, \{Lin Yang\} and Wang, \{Sin Ling\} and Wu, \{Jui Jen\}",

note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media, LLC.",

year = "2017",

doi = "10.1007/s10600-017-2082-4",

language = "英语",

volume = "53",

pages = "649--652",

journal = "Chemistry of Natural Compounds",

issn = "0009-3130",

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number = "4",

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TY - JOUR

T1 - A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

AU - Chen, Jih Jung

AU - Hung, Ming Chi

AU - Liao, Hsiang Ruei

AU - Kuo, Yueh Hsiung

AU - Shu, Chih Wen

AU - Sung, Ping Jyun

AU - Lim, Yun Ping

AU - Kuo, Wen Lung

AU - Cheng, Lin Yang

AU - Wang, Sin Ling

AU - Wu, Jui Jen

PY - 2017

Y1 - 2017

N2 - A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation.

AB - A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation.

KW - Garcinia subelliptica

KW - Guttiferae

KW - anti-inflammatory activity

KW - garcisubellone

KW - root

KW - xanthone

UR - https://www.scopus.com/pages/publications/85025160981

U2 - 10.1007/s10600-017-2082-4

DO - 10.1007/s10600-017-2082-4

M3 - 文章

AN - SCOPUS:85025160981

SN - 0009-3130

VL - 53

SP - 649

EP - 652

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

IS - 4

ER -

A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

Abstract

Bibliographical note

Keywords

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