A nomogram for predicting the probability of recurrence in patients with carcinomas located in the ampulla of Vater

Keng Hao Liu, Chih Ho Hsu, Jun Te Hsu, Chun Yi Tsai, Yu Yin Liu, Tsann Long Hwang, Ta Sen Yeh, Yu Shin Hung, Wen Chi Chou*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations


(CAV) is surgical resection. Nevertheless, recurrence is observed in half of the patients within five years after cancer surgery. In this study, we aimed to identify predictive factors and develop a nomogram capable of predicting the risk of recurrence in post-resection CAV patients. Methods: Our study cohort was composed of two hundred and twelve patients who had undergone radical surgery for CAV between 2000 and 2012. Clinicopathological variables predictive of recurrence were identified using univariate analysis. A Cox proportional hazards model was used to select the predictive factors used for the nomogram. Results: The 5-year overall survival, cancer-specific survival and disease-free survival rates were 44.3%, 51.1%, and 42.8%, respectively. The five most predictive variables for tumor recurrence were chosen to develop the nomogram. The nomogram had a highly predictive performance, with a bootstrap-corrected concordance index of 0.72 (95% confidence interval, 0.67-0.79). Furthermore, the performance of the nomogram was found to be better than the American Joint Committee on Cancer (AJCC) staging system due to better homogeneity, higher ability of discrimination and higher risk stratification of the model. Conclusions: We developed a predictive nomogram for estimating tumor relapse probability in CAV patients after radical surgery. This nomogram might be more informative than the AJCC staging system and may allow for better estimation of the probability of relapse after surgical resections.

Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalJournal of Cancer
Issue number3
StatePublished - 2017


  • Ccalibration
  • Nomogram
  • Recurrence probability
  • Words: Ampulla vater cancer


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