A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

Yu Ming Chung; Fang Rong Chang; Tseng Fu Tseng; Tsong Long Hwang; Lei Chin Chen; Shou Fang Wu; Chia Lin Lee; Zu Yau Lin; Li Yeh Chuang; Jinu Huang Su; Yang Chang Wu

doi:10.1016/j.bmcl.2011.01.067

A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

Yu Ming Chung, Fang Rong Chang, Tseng Fu Tseng, Tsong Long Hwang, Lei Chin Chen, Shou Fang Wu, Chia Lin Lee, Zu Yau Lin, Li Yeh Chuang, Jinu Huang Su^*, Yang Chang Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC ₅₀ value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively.

Original language	English
Pages (from-to)	1792-1794
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2011.01.067
State	Published - 15 03 2011

Keywords

Anti-inflammatory
Aristolamide II
Aristolochia manshuriensis
Aristopyridinone A
Elastase release
Human neutrophils
Phenanthrene
Superoxide anion

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2011.01.067

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@article{4285a96325df471ead126462de941131,

title = "A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis",

abstract = "A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC 50 value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.",

keywords = "Anti-inflammatory, Aristolamide II, Aristolochia manshuriensis, Aristopyridinone A, Elastase release, Human neutrophils, Phenanthrene, Superoxide anion",

author = "Chung, {Yu Ming} and Chang, {Fang Rong} and Tseng, {Tseng Fu} and Hwang, {Tsong Long} and Chen, {Lei Chin} and Wu, {Shou Fang} and Lee, {Chia Lin} and Lin, {Zu Yau} and Chuang, {Li Yeh} and Su, {Jinu Huang} and Wu, {Yang Chang}",

year = "2011",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2011.01.067",

language = "英语",

volume = "21",

pages = "1792--1794",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

AU - Chung, Yu Ming

AU - Chang, Fang Rong

AU - Tseng, Tseng Fu

AU - Hwang, Tsong Long

AU - Chen, Lei Chin

AU - Wu, Shou Fang

AU - Lee, Chia Lin

AU - Lin, Zu Yau

AU - Chuang, Li Yeh

AU - Su, Jinu Huang

AU - Wu, Yang Chang

PY - 2011/3/15

Y1 - 2011/3/15

N2 - A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC 50 value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.

AB - A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC 50 value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively.

KW - Anti-inflammatory

KW - Aristolamide II

KW - Aristolochia manshuriensis

KW - Aristopyridinone A

KW - Elastase release

KW - Human neutrophils

KW - Phenanthrene

KW - Superoxide anion

UR - http://www.scopus.com/inward/record.url?scp=79952360536&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2011.01.067

DO - 10.1016/j.bmcl.2011.01.067

M3 - 文章

C2 - 21353775

AN - SCOPUS:79952360536

SN - 0960-894X

VL - 21

SP - 1792

EP - 1794

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

Abstract

Keywords

UN SDGs

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