A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening

Wen Bin Lee; Kuo Wei Hsu; Huey Ling You; Mel S. Lee; Gwo Bin Lee

doi:10.1109/TRANSDUCERS.2019.8808727

A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening

Wen Bin Lee, Kuo Wei Hsu, Huey Ling You, Mel S. Lee, Gwo Bin Lee^*

^*Corresponding author for this work

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

This study reported a portable microfluidic system which can be used to automatically perform antibiotic screening with single antibiotic, double antibiotic combinations and even triple antibiotic combinations on clinically isolated bacteria strains. With the incorporation of the integrated pneumatically-driven microfluidic chip, a pneumatic control module, a temperature control module, and an optical detection module, the developed system was capable of achieving significant improvement of operation flexibility as well as cost reduction for determination of antimicrobial susceptibility test and the efficacy of drug combinations via colorimetric results within 4 hours. Personalized antibiotic screening may be realized by using the developed microfluidic system for rapid clinical decision-making.

Original language	English
Title of host publication	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1002-1004
Number of pages	3
ISBN (Electronic)	9781728120072
DOIs	https://doi.org/10.1109/TRANSDUCERS.2019.8808727
State	Published - 06 2019
Event	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany Duration: 23 06 2019 → 27 06 2019

Publication series

Name	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Country/Territory	Germany
City	Berlin
Period	23/06/19 → 27/06/19

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

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10.1109/TRANSDUCERS.2019.8808727

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Lee, W. B., Hsu, K. W., You, H. L., Lee, M. S., & Lee, G. B. (2019). A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (pp. 1002-1004). Article 8808727 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2019.8808727

Lee, Wen Bin ; Hsu, Kuo Wei ; You, Huey Ling et al. / A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening. 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1002-1004 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

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title = "A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening",

abstract = "This study reported a portable microfluidic system which can be used to automatically perform antibiotic screening with single antibiotic, double antibiotic combinations and even triple antibiotic combinations on clinically isolated bacteria strains. With the incorporation of the integrated pneumatically-driven microfluidic chip, a pneumatic control module, a temperature control module, and an optical detection module, the developed system was capable of achieving significant improvement of operation flexibility as well as cost reduction for determination of antimicrobial susceptibility test and the efficacy of drug combinations via colorimetric results within 4 hours. Personalized antibiotic screening may be realized by using the developed microfluidic system for rapid clinical decision-making.",

author = "Lee, {Wen Bin} and Hsu, {Kuo Wei} and You, {Huey Ling} and Lee, {Mel S.} and Lee, {Gwo Bin}",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII ; Conference date: 23-06-2019 Through 27-06-2019",

year = "2019",

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doi = "10.1109/TRANSDUCERS.2019.8808727",

language = "英语",

series = "2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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Lee, WB, Hsu, KW, You, HL, Lee, MS & Lee, GB 2019, A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening. in 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII., 8808727, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Institute of Electrical and Electronics Engineers Inc., pp. 1002-1004, 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Berlin, Germany, 23/06/19. https://doi.org/10.1109/TRANSDUCERS.2019.8808727

A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening. / Lee, Wen Bin; Hsu, Kuo Wei; You, Huey Ling et al.
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1002-1004 8808727 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Lee WB, Hsu KW, You HL, Lee MS, Lee GB. A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1002-1004. 8808727. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). doi: 10.1109/TRANSDUCERS.2019.8808727

A Portable, Automatic Microfluidic System for Rapid Personalized Antibiotic Screening

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