A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

Ho Chang Kuo; Yu Wen Hsu; Chung Min Wu; Shawn Hsiang Yin Chen; Kuo Sheng Hung; Wei Pin Chang; Kuender D. Yang; Kai Sheng Hsieh; Wei Chiao Chen; Yoshihiro Onouchi; Wei Chiao Chang

doi:10.1371/journal.pone.0069685

A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

Ho Chang Kuo
, Yu Wen Hsu
, Chung Min Wu
, Shawn Hsiang Yin Chen
, Kuo Sheng Hung
, Wei Pin Chang
, Kuender D. Yang
, Kai Sheng Hsieh
, Wei Chiao Chen
, Yoshihiro Onouchi
, Wei Chiao Chang^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

41 Scopus citations

Abstract

Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.

Original language	English
Article number	e69685
Journal	PLoS ONE
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0069685
State	Published - 24 07 2013

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Kuo, H. C., Hsu, Y. W., Wu, C. M., Chen, S. H. Y., Hung, K. S., Chang, W. P., Yang, K. D., Hsieh, K. S., Chen, W. C., Onouchi, Y., & Chang, W. C. (2013). A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease. PLoS ONE, 8(7), Article e69685. https://doi.org/10.1371/journal.pone.0069685

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title = "A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease",

abstract = "Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.",

author = "Kuo, \{Ho Chang\} and Hsu, \{Yu Wen\} and Wu, \{Chung Min\} and Chen, \{Shawn Hsiang Yin\} and Hung, \{Kuo Sheng\} and Chang, \{Wei Pin\} and Yang, \{Kuender D.\} and Hsieh, \{Kai Sheng\} and Chen, \{Wei Chiao\} and Yoshihiro Onouchi and Chang, \{Wei Chiao\}",

year = "2013",

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doi = "10.1371/journal.pone.0069685",

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T1 - A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

AU - Kuo, Ho Chang

AU - Hsu, Yu Wen

AU - Wu, Chung Min

AU - Chen, Shawn Hsiang Yin

AU - Hung, Kuo Sheng

AU - Chang, Wei Pin

AU - Yang, Kuender D.

AU - Hsieh, Kai Sheng

AU - Chen, Wei Chiao

AU - Onouchi, Yoshihiro

AU - Chang, Wei Chiao

PY - 2013/7/24

Y1 - 2013/7/24

N2 - Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.

AB - Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.

UR - https://www.scopus.com/pages/publications/84880826298

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DO - 10.1371/journal.pone.0069685

M3 - 文章

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SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e69685

ER -

A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

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