A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma

Yu Lun Tsai; Po Fan Hsieh; Wei Yu Lin; Hsin Hao Su; Cheng Keng Chuang; Ying Hsu Chang; Heng Chang Chuang; Kai Jie Yu; I. Hung Shao; Chao Hsiang Chang; Hsi Chin Wu; Kuo Liang Chen; Chi Ping Huang; Shuo Meng Wand; Po Hui Chiang; Yunan Tso Cheng; Wei Ching Lee; See Tong Pang

doi:10.1016/j.urols.2013.06.002

A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma

Yu Lun Tsai
, Po Fan Hsieh
, Wei Yu Lin
, Hsin Hao Su
, Cheng Keng Chuang
, Ying Hsu Chang
, Heng Chang Chuang
, Kai Jie Yu
, I. Hung Shao
, Chao Hsiang Chang
, Hsi Chin Wu
, Kuo Liang Chen
, Chi Ping Huang
, Shuo Meng Wand
, Po Hui Chiang
, Yunan Tso Cheng
, Wei Ching Lee
, See Tong Pang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

Abstract

Objective: To assess the clinical characteristics, prognostic factors, and treatment outcomes of primary testicular lymphoma (PTL). Materials and Methods: We reviewed the medical records of PTL patients diagnosed between January 2000 and May 2012 at four hospitals in Taiwan. The following data were collected and analyzed: patient age at diagnosis, B symptoms (fever, night sweats, and/or weight loss), tumor localization (diffuse or testis alone), tumor site (left, right, or bilateral), stage of disease, histological pattern, International Prognostic Index, treatment method and outcome, relapse, and survival time. Kaplan-Meier curves were constructed to assess the effects of various factors on patient survival. Results: Thirty patients with PTL were included in this study. The median age at diagnosis was 62.5 years (range: 19-89 years) and median overall survival (OS) was 44 months. The majority of the patients had unilateral lymphoma, stage I/II disease, and diffuse large B-cell lymphoma. An absence of B symptoms, limited disease stage, lymphoma localized to testis only, and orchidectomy were considered to be significantly favorable prognostic factors of OS (p<0.05). The PTL treatment regimen varied among patients and included orchidectomy, chemotherapy, and/or radiotherapy. Interestingly, although 50% patients achieved complete remission (CR) post-treatment, relapse was observed in 42% patients during the follow-up period. Nonetheless, patients who initially underwent orchidectomy appeared to have a significantly better survival rate, whereas chemotherapy proved more advantageous for those with the diffuse-type PTL. Conclusion: PTL is characterized by unique clinical features and prognostic factors. Despite differing treatment regimens, 50% of patients achieved CR. Patients with testicular localization who underwent orchidectomy may achieve better outcomes, whereas chemotherapy proved to be beneficial in those with diffuse-type PTL.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Urological Science
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.urols.2013.06.002
State	Published - 09 2013
Externally published	Yes

Keywords

Outcomes
Primary testicular lymphoma
Prognosis
Relapse
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.urols.2013.06.002

Cite this

Tsai, Y. L., Hsieh, P. F., Lin, W. Y., Su, H. H., Chuang, C. K., Chang, Y. H., Chuang, H. C., Yu, K. J., Shao, I. H., Chang, C. H., Wu, H. C., Chen, K. L., Huang, C. P., Wand, S. M., Chiang, P. H., Cheng, Y. T., Lee, W. C., & Pang, S. T. (2013). A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma. Urological Science, 24(3), 89-93. https://doi.org/10.1016/j.urols.2013.06.002

@article{9aa08890bb8a4a138e8a49061ed8d044,

title = "A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma",

abstract = "Objective: To assess the clinical characteristics, prognostic factors, and treatment outcomes of primary testicular lymphoma (PTL). Materials and Methods: We reviewed the medical records of PTL patients diagnosed between January 2000 and May 2012 at four hospitals in Taiwan. The following data were collected and analyzed: patient age at diagnosis, B symptoms (fever, night sweats, and/or weight loss), tumor localization (diffuse or testis alone), tumor site (left, right, or bilateral), stage of disease, histological pattern, International Prognostic Index, treatment method and outcome, relapse, and survival time. Kaplan-Meier curves were constructed to assess the effects of various factors on patient survival. Results: Thirty patients with PTL were included in this study. The median age at diagnosis was 62.5 years (range: 19-89 years) and median overall survival (OS) was 44 months. The majority of the patients had unilateral lymphoma, stage I/II disease, and diffuse large B-cell lymphoma. An absence of B symptoms, limited disease stage, lymphoma localized to testis only, and orchidectomy were considered to be significantly favorable prognostic factors of OS (p<0.05). The PTL treatment regimen varied among patients and included orchidectomy, chemotherapy, and/or radiotherapy. Interestingly, although 50\% patients achieved complete remission (CR) post-treatment, relapse was observed in 42\% patients during the follow-up period. Nonetheless, patients who initially underwent orchidectomy appeared to have a significantly better survival rate, whereas chemotherapy proved more advantageous for those with the diffuse-type PTL. Conclusion: PTL is characterized by unique clinical features and prognostic factors. Despite differing treatment regimens, 50\% of patients achieved CR. Patients with testicular localization who underwent orchidectomy may achieve better outcomes, whereas chemotherapy proved to be beneficial in those with diffuse-type PTL.",

keywords = "Outcomes, Primary testicular lymphoma, Prognosis, Relapse, Treatment",

author = "Tsai, \{Yu Lun\} and Hsieh, \{Po Fan\} and Lin, \{Wei Yu\} and Su, \{Hsin Hao\} and Chuang, \{Cheng Keng\} and Chang, \{Ying Hsu\} and Chuang, \{Heng Chang\} and Yu, \{Kai Jie\} and Shao, \{I. Hung\} and Chang, \{Chao Hsiang\} and Wu, \{Hsi Chin\} and Chen, \{Kuo Liang\} and Huang, \{Chi Ping\} and Wand, \{Shuo Meng\} and Chiang, \{Po Hui\} and Cheng, \{Yunan Tso\} and Lee, \{Wei Ching\} and Pang, \{See Tong\}",

year = "2013",

month = sep,

doi = "10.1016/j.urols.2013.06.002",

language = "英语",

volume = "24",

pages = "89--93",

journal = "Urological Science",

issn = "1879-5226",

publisher = "Wolters Kluwer Medknow Publications",

number = "3",

}

Tsai, YL, Hsieh, PF, Lin, WY, Su, HH, Chuang, CK, Chang, YH, Chuang, HC, Yu, KJ, Shao, IH, Chang, CH, Wu, HC, Chen, KL, Huang, CP, Wand, SM, Chiang, PH, Cheng, YT, Lee, WC & Pang, ST 2013, 'A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma', Urological Science, vol. 24, no. 3, pp. 89-93. https://doi.org/10.1016/j.urols.2013.06.002

TY - JOUR

T1 - A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma

AU - Tsai, Yu Lun

AU - Hsieh, Po Fan

AU - Lin, Wei Yu

AU - Su, Hsin Hao

AU - Chuang, Cheng Keng

AU - Chang, Ying Hsu

AU - Chuang, Heng Chang

AU - Yu, Kai Jie

AU - Shao, I. Hung

AU - Chang, Chao Hsiang

AU - Wu, Hsi Chin

AU - Chen, Kuo Liang

AU - Huang, Chi Ping

AU - Wand, Shuo Meng

AU - Chiang, Po Hui

AU - Cheng, Yunan Tso

AU - Lee, Wei Ching

AU - Pang, See Tong

PY - 2013/9

Y1 - 2013/9

N2 - Objective: To assess the clinical characteristics, prognostic factors, and treatment outcomes of primary testicular lymphoma (PTL). Materials and Methods: We reviewed the medical records of PTL patients diagnosed between January 2000 and May 2012 at four hospitals in Taiwan. The following data were collected and analyzed: patient age at diagnosis, B symptoms (fever, night sweats, and/or weight loss), tumor localization (diffuse or testis alone), tumor site (left, right, or bilateral), stage of disease, histological pattern, International Prognostic Index, treatment method and outcome, relapse, and survival time. Kaplan-Meier curves were constructed to assess the effects of various factors on patient survival. Results: Thirty patients with PTL were included in this study. The median age at diagnosis was 62.5 years (range: 19-89 years) and median overall survival (OS) was 44 months. The majority of the patients had unilateral lymphoma, stage I/II disease, and diffuse large B-cell lymphoma. An absence of B symptoms, limited disease stage, lymphoma localized to testis only, and orchidectomy were considered to be significantly favorable prognostic factors of OS (p<0.05). The PTL treatment regimen varied among patients and included orchidectomy, chemotherapy, and/or radiotherapy. Interestingly, although 50% patients achieved complete remission (CR) post-treatment, relapse was observed in 42% patients during the follow-up period. Nonetheless, patients who initially underwent orchidectomy appeared to have a significantly better survival rate, whereas chemotherapy proved more advantageous for those with the diffuse-type PTL. Conclusion: PTL is characterized by unique clinical features and prognostic factors. Despite differing treatment regimens, 50% of patients achieved CR. Patients with testicular localization who underwent orchidectomy may achieve better outcomes, whereas chemotherapy proved to be beneficial in those with diffuse-type PTL.

AB - Objective: To assess the clinical characteristics, prognostic factors, and treatment outcomes of primary testicular lymphoma (PTL). Materials and Methods: We reviewed the medical records of PTL patients diagnosed between January 2000 and May 2012 at four hospitals in Taiwan. The following data were collected and analyzed: patient age at diagnosis, B symptoms (fever, night sweats, and/or weight loss), tumor localization (diffuse or testis alone), tumor site (left, right, or bilateral), stage of disease, histological pattern, International Prognostic Index, treatment method and outcome, relapse, and survival time. Kaplan-Meier curves were constructed to assess the effects of various factors on patient survival. Results: Thirty patients with PTL were included in this study. The median age at diagnosis was 62.5 years (range: 19-89 years) and median overall survival (OS) was 44 months. The majority of the patients had unilateral lymphoma, stage I/II disease, and diffuse large B-cell lymphoma. An absence of B symptoms, limited disease stage, lymphoma localized to testis only, and orchidectomy were considered to be significantly favorable prognostic factors of OS (p<0.05). The PTL treatment regimen varied among patients and included orchidectomy, chemotherapy, and/or radiotherapy. Interestingly, although 50% patients achieved complete remission (CR) post-treatment, relapse was observed in 42% patients during the follow-up period. Nonetheless, patients who initially underwent orchidectomy appeared to have a significantly better survival rate, whereas chemotherapy proved more advantageous for those with the diffuse-type PTL. Conclusion: PTL is characterized by unique clinical features and prognostic factors. Despite differing treatment regimens, 50% of patients achieved CR. Patients with testicular localization who underwent orchidectomy may achieve better outcomes, whereas chemotherapy proved to be beneficial in those with diffuse-type PTL.

KW - Outcomes

KW - Primary testicular lymphoma

KW - Prognosis

KW - Relapse

KW - Treatment

UR - https://www.scopus.com/pages/publications/84883804342

U2 - 10.1016/j.urols.2013.06.002

DO - 10.1016/j.urols.2013.06.002

M3 - 文章

AN - SCOPUS:84883804342

SN - 1879-5226

VL - 24

SP - 89

EP - 93

JO - Urological Science

JF - Urological Science

IS - 3

ER -

A retrospective study of clinical characteristics and prognostic factors of primary testicular lymphoma

Abstract

Keywords

UN SDGs

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