A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Hiroshi Suzuki; Yukiko Kurihara; Motohiro Takeya; Nobuo Kamada; Motoyuki Kataoka; Kouichi Jishage; Otoya Ueda; Hisashi Sakaguchi; Takayuki Higashi; Tsukasa Suzuki; Yoshiaki Takashima; Yoshiki Kawabe; Osamu Cynshi; Youichiro Wada; Makoto Honda; Hiroki Kurihara; Hiroyuki Aburatani; Takefumi Doi; Akiyo Matsumoto; Sadahiro Azuma; Tetsuo Noda; Yutaka Toyoda; Hiroshige Itakura; Yoshio Yazaki; Seikoh Horiuchi; Kiyoshi Takahashi; J. Kar Kruijt; Theo J.C. Van Berkel; Urs P. Steinbrecher; Shun Ishibashi; Nobuyo Maeda; Siamon Gordon; Tatsuhiko Kodama

doi:10.1038/386292a0

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Hiroshi Suzuki, Yukiko Kurihara, Motohiro Takeya, Nobuo Kamada, Motoyuki Kataoka, Kouichi Jishage, Otoya Ueda, Hisashi Sakaguchi, Takayuki Higashi, Tsukasa Suzuki, Yoshiaki Takashima, Yoshiki Kawabe, Osamu Cynshi, Youichiro Wada, Makoto Honda, Hiroki Kurihara, Hiroyuki Aburatani, Takefumi Doi, Akiyo Matsumoto, Sadahiro AzumaTetsuo Noda, Yutaka Toyoda, Hiroshige Itakura, Yoshio Yazaki, Seikoh Horiuchi, Kiyoshi Takahashi, J. Kar Kruijt, Theo J.C. Van Berkel, Urs P. Steinbrecher, Shun Ishibashi, Nobuyo Maeda, Siamon Gordon, Tatsuhiko Kodama^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1061 Scopus citations

Abstract

Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in on animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

Original language	English
Pages (from-to)	292-296
Number of pages	5
Journal	Nature
Volume	386
Issue number	6622
DOIs	https://doi.org/10.1038/386292a0
State	Published - 20 03 1997
Externally published	Yes

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Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., Takashima, Y., Kawabe, Y., Cynshi, O., Wada, Y., Honda, M., Kurihara, H., Aburatani, H., Doi, T., Matsumoto, A., ... Kodama, T. (1997). A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature, 386(6622), 292-296. https://doi.org/10.1038/386292a0

@article{51400b3598b445dd8a17064e38274c99,

title = "A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection",

abstract = "Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in on animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.",

author = "Hiroshi Suzuki and Yukiko Kurihara and Motohiro Takeya and Nobuo Kamada and Motoyuki Kataoka and Kouichi Jishage and Otoya Ueda and Hisashi Sakaguchi and Takayuki Higashi and Tsukasa Suzuki and Yoshiaki Takashima and Yoshiki Kawabe and Osamu Cynshi and Youichiro Wada and Makoto Honda and Hiroki Kurihara and Hiroyuki Aburatani and Takefumi Doi and Akiyo Matsumoto and Sadahiro Azuma and Tetsuo Noda and Yutaka Toyoda and Hiroshige Itakura and Yoshio Yazaki and Seikoh Horiuchi and Kiyoshi Takahashi and Kruijt, \{J. Kar\} and \{Van Berkel\}, \{Theo J.C.\} and Steinbrecher, \{Urs P.\} and Shun Ishibashi and Nobuyo Maeda and Siamon Gordon and Tatsuhiko Kodama",

year = "1997",

month = mar,

day = "20",

doi = "10.1038/386292a0",

language = "英语",

volume = "386",

pages = "292--296",

journal = "Nature",

issn = "0028-0836",

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Suzuki, H, Kurihara, Y, Takeya, M, Kamada, N, Kataoka, M, Jishage, K, Ueda, O, Sakaguchi, H, Higashi, T, Suzuki, T, Takashima, Y, Kawabe, Y, Cynshi, O, Wada, Y, Honda, M, Kurihara, H, Aburatani, H, Doi, T, Matsumoto, A, Azuma, S, Noda, T, Toyoda, Y, Itakura, H, Yazaki, Y, Horiuchi, S, Takahashi, K, Kruijt, JK, Van Berkel, TJC, Steinbrecher, UP, Ishibashi, S, Maeda, N, Gordon, S & Kodama, T 1997, 'A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection', Nature, vol. 386, no. 6622, pp. 292-296. https://doi.org/10.1038/386292a0

TY - JOUR

T1 - A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

AU - Suzuki, Hiroshi

AU - Kurihara, Yukiko

AU - Takeya, Motohiro

AU - Kamada, Nobuo

AU - Kataoka, Motoyuki

AU - Jishage, Kouichi

AU - Ueda, Otoya

AU - Sakaguchi, Hisashi

AU - Higashi, Takayuki

AU - Suzuki, Tsukasa

AU - Takashima, Yoshiaki

AU - Kawabe, Yoshiki

AU - Cynshi, Osamu

AU - Wada, Youichiro

AU - Honda, Makoto

AU - Kurihara, Hiroki

AU - Aburatani, Hiroyuki

AU - Doi, Takefumi

AU - Matsumoto, Akiyo

AU - Azuma, Sadahiro

AU - Noda, Tetsuo

AU - Toyoda, Yutaka

AU - Itakura, Hiroshige

AU - Yazaki, Yoshio

AU - Horiuchi, Seikoh

AU - Takahashi, Kiyoshi

AU - Kruijt, J. Kar

AU - Van Berkel, Theo J.C.

AU - Steinbrecher, Urs P.

AU - Ishibashi, Shun

AU - Maeda, Nobuyo

AU - Gordon, Siamon

AU - Kodama, Tatsuhiko

PY - 1997/3/20

Y1 - 1997/3/20

N2 - Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in on animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

AB - Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in on animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

UR - https://www.scopus.com/pages/publications/0030895048

U2 - 10.1038/386292a0

DO - 10.1038/386292a0

M3 - 文章

C2 - 9069289

AN - SCOPUS:0030895048

SN - 0028-0836

VL - 386

SP - 292

EP - 296

JO - Nature

JF - Nature

IS - 6622

ER -

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

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