A simple preoperative model to predict overall survival of patients undergoing liver resection for hepatocellular carcinoma ≥10 cm

Yi Hao Yen; Wei Feng Li; Yueh Wei Liu; Chee Chien Yong; Chih Chi Wang; Chih Yun Lin

doi:10.1016/j.hpb.2023.07.881

A simple preoperative model to predict overall survival of patients undergoing liver resection for hepatocellular carcinoma ≥10 cm

Yi Hao Yen^*, Wei Feng Li, Yueh Wei Liu, Chee Chien Yong, Chih Chi Wang^*, Chih Yun Lin

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

Abstract

BACKGROUND: Studies have rarely reported on preoperative predictors of prognosis of patients undergoing liver resection (LR) for HCC ≥10 cm. We developed a simple model to predict overall survival (OS) of these patients.

METHODS: We enrolled 305 patients with HCC ≥10 cm undergoing LR. Cirrhosis and imaging-defined AJCC stage were used to develop a preoperative model. Patients were divided into three groups based on the Kaplan-Meier estimator.

RESULTS: Group 1 included patients with AJCC stage 1 and no cirrhosis (n = 86), group 2 those with AJCC stage 1 and cirrhosis plus those with AJCC stage 2 or 3 and no cirrhosis (n = 166), and group 3 those with AJCC stage 2 or 3 and cirrhosis (n = 51). The five-year OS of group 1, 2, and 3 was 55%, 32%, and 25%, respectively (p < 0.001). With group 1 as the reference, multivariate analysis of OS showed that group 2 (HR = 2.043; 95% CI = 1.332-3.134; p = 0.001) and group 3 (HR = 2.740; 95% CI = 1.645-4.564; p < 0.001) were independent predictors of OS.

CONCLUSION: We developed a simple model to predict OS of patients undergoing LR for HCC ≥10 cm.

Original language	English
Pages (from-to)	1373-1381
Number of pages	9
Journal	HPB
Volume	25
Issue number	11
DOIs	https://doi.org/10.1016/j.hpb.2023.07.881
State	Published - 11 2023
Externally published	Yes

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10.1016/j.hpb.2023.07.881

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@article{a6d986f309544d6fba5fd9fa3535161f,

title = "A simple preoperative model to predict overall survival of patients undergoing liver resection for hepatocellular carcinoma ≥10 cm",

abstract = "BACKGROUND: Studies have rarely reported on preoperative predictors of prognosis of patients undergoing liver resection (LR) for HCC ≥10 cm. We developed a simple model to predict overall survival (OS) of these patients.METHODS: We enrolled 305 patients with HCC ≥10 cm undergoing LR. Cirrhosis and imaging-defined AJCC stage were used to develop a preoperative model. Patients were divided into three groups based on the Kaplan-Meier estimator.RESULTS: Group 1 included patients with AJCC stage 1 and no cirrhosis (n = 86), group 2 those with AJCC stage 1 and cirrhosis plus those with AJCC stage 2 or 3 and no cirrhosis (n = 166), and group 3 those with AJCC stage 2 or 3 and cirrhosis (n = 51). The five-year OS of group 1, 2, and 3 was 55\%, 32\%, and 25\%, respectively (p < 0.001). With group 1 as the reference, multivariate analysis of OS showed that group 2 (HR = 2.043; 95\% CI = 1.332-3.134; p = 0.001) and group 3 (HR = 2.740; 95\% CI = 1.645-4.564; p < 0.001) were independent predictors of OS.CONCLUSION: We developed a simple model to predict OS of patients undergoing LR for HCC ≥10 cm.",

author = "Yen, \{Yi Hao\} and Li, \{Wei Feng\} and Liu, \{Yueh Wei\} and Yong, \{Chee Chien\} and Wang, \{Chih Chi\} and Lin, \{Chih Yun\}",

year = "2023",

month = nov,

doi = "10.1016/j.hpb.2023.07.881",

language = "英语",

volume = "25",

pages = "1373--1381",

journal = "HPB",

issn = "1365-182X",

publisher = "Elsevier B.V.",

number = "11",

}

TY - JOUR

T1 - A simple preoperative model to predict overall survival of patients undergoing liver resection for hepatocellular carcinoma ≥10 cm

AU - Yen, Yi Hao

AU - Li, Wei Feng

AU - Liu, Yueh Wei

AU - Yong, Chee Chien

AU - Wang, Chih Chi

AU - Lin, Chih Yun

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: Studies have rarely reported on preoperative predictors of prognosis of patients undergoing liver resection (LR) for HCC ≥10 cm. We developed a simple model to predict overall survival (OS) of these patients.METHODS: We enrolled 305 patients with HCC ≥10 cm undergoing LR. Cirrhosis and imaging-defined AJCC stage were used to develop a preoperative model. Patients were divided into three groups based on the Kaplan-Meier estimator.RESULTS: Group 1 included patients with AJCC stage 1 and no cirrhosis (n = 86), group 2 those with AJCC stage 1 and cirrhosis plus those with AJCC stage 2 or 3 and no cirrhosis (n = 166), and group 3 those with AJCC stage 2 or 3 and cirrhosis (n = 51). The five-year OS of group 1, 2, and 3 was 55%, 32%, and 25%, respectively (p < 0.001). With group 1 as the reference, multivariate analysis of OS showed that group 2 (HR = 2.043; 95% CI = 1.332-3.134; p = 0.001) and group 3 (HR = 2.740; 95% CI = 1.645-4.564; p < 0.001) were independent predictors of OS.CONCLUSION: We developed a simple model to predict OS of patients undergoing LR for HCC ≥10 cm.

AB - BACKGROUND: Studies have rarely reported on preoperative predictors of prognosis of patients undergoing liver resection (LR) for HCC ≥10 cm. We developed a simple model to predict overall survival (OS) of these patients.METHODS: We enrolled 305 patients with HCC ≥10 cm undergoing LR. Cirrhosis and imaging-defined AJCC stage were used to develop a preoperative model. Patients were divided into three groups based on the Kaplan-Meier estimator.RESULTS: Group 1 included patients with AJCC stage 1 and no cirrhosis (n = 86), group 2 those with AJCC stage 1 and cirrhosis plus those with AJCC stage 2 or 3 and no cirrhosis (n = 166), and group 3 those with AJCC stage 2 or 3 and cirrhosis (n = 51). The five-year OS of group 1, 2, and 3 was 55%, 32%, and 25%, respectively (p < 0.001). With group 1 as the reference, multivariate analysis of OS showed that group 2 (HR = 2.043; 95% CI = 1.332-3.134; p = 0.001) and group 3 (HR = 2.740; 95% CI = 1.645-4.564; p < 0.001) were independent predictors of OS.CONCLUSION: We developed a simple model to predict OS of patients undergoing LR for HCC ≥10 cm.

UR - https://www.scopus.com/pages/publications/85166678466

U2 - 10.1016/j.hpb.2023.07.881

DO - 10.1016/j.hpb.2023.07.881

M3 - 文章

C2 - 37517893

AN - SCOPUS:85166678466

SN - 1365-182X

VL - 25

SP - 1373

EP - 1381

JO - HPB

JF - HPB

IS - 11

ER -

A simple preoperative model to predict overall survival of patients undergoing liver resection for hepatocellular carcinoma ≥10 cm

Abstract

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