TY - JOUR
T1 - A simplified regimen of weekly high dose 5-fluorouracil and leucovorin as a 24-hour infusion in patients with advanced colorectal carcinoma
AU - Yang, Tsai Shen
AU - Hsu, Kuan Cheng
AU - Chiang, Jy Ming
AU - Tang, Reiping
AU - Chen, Jinn Shium
AU - Changchien, Chung Rong
AU - Wang, Jeng Yi
PY - 1999/5/1
Y1 - 1999/5/1
N2 - BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly 24-hour infusion of high dose 5-FU combined with a relatively low dose of LV was used to treat patients with advanced colorectal carcinoma. METHODS. Thirty-six patients with advanced colorectal carcinoma received 5-FU, 2600 mg/m2, admixed with LV, 100 mg/m2, in a portable infusion pump administered intravenously over a 24-hour period. High dose 5-FU/LV was delivered once a week for 5 consecutive weeks followed by a 1-week recovery period. All patients were assessable for toxicity and response. RESULTS. Two complete responses and 15 partial responses were observed (response rate of 47.2%; 95% confidence interval, 30.1-64.4%). The median response duration was 9.6 months. The median survival and time to progression were 11.9 months and 7.1 months, respectively. The toxicity was mild and acceptable. The major dose- limiting factors were hand-foot syndrome and fatigue. CONCLUSIONS. This simplified regimen of weekly 24-hour continuous infusion of high dose 5- FU/LV is an effective regimen in the treatment of patients with advanced colorectal carcinoma. Further study of the pharmacokinetics of combination therapy with 5-FU and LV as used in this regimen and its correlation with response and toxicity is warranted.
AB - BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly 24-hour infusion of high dose 5-FU combined with a relatively low dose of LV was used to treat patients with advanced colorectal carcinoma. METHODS. Thirty-six patients with advanced colorectal carcinoma received 5-FU, 2600 mg/m2, admixed with LV, 100 mg/m2, in a portable infusion pump administered intravenously over a 24-hour period. High dose 5-FU/LV was delivered once a week for 5 consecutive weeks followed by a 1-week recovery period. All patients were assessable for toxicity and response. RESULTS. Two complete responses and 15 partial responses were observed (response rate of 47.2%; 95% confidence interval, 30.1-64.4%). The median response duration was 9.6 months. The median survival and time to progression were 11.9 months and 7.1 months, respectively. The toxicity was mild and acceptable. The major dose- limiting factors were hand-foot syndrome and fatigue. CONCLUSIONS. This simplified regimen of weekly 24-hour continuous infusion of high dose 5- FU/LV is an effective regimen in the treatment of patients with advanced colorectal carcinoma. Further study of the pharmacokinetics of combination therapy with 5-FU and LV as used in this regimen and its correlation with response and toxicity is warranted.
KW - Advanced colorectal carcinoma
KW - High dose 5- fluorouracil
KW - Leucovorin
KW - Weekly 24-hour infusion
UR - http://www.scopus.com/inward/record.url?scp=0033135341&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19990501)85:9<1925::AID-CNCR7>3.0.CO;2-Q
DO - 10.1002/(SICI)1097-0142(19990501)85:9<1925::AID-CNCR7>3.0.CO;2-Q
M3 - 文章
C2 - 10223231
AN - SCOPUS:0033135341
SN - 0008-543X
VL - 85
SP - 1925
EP - 1930
JO - Cancer
JF - Cancer
IS - 9
ER -