A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction

Po Hung Kuo; Jui Chang Kuo; Hsiao Ting Hsueh; Jian Yu Hsieh; Yi Chun Huang; Tao Wang; Yen Hung Lin; Chih Ting Lin; Yao Joe Yang; Shey Shi Lu

doi:10.1109/TBCAS.2015.2507618

A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction

Po Hung Kuo, Jui Chang Kuo, Hsiao Ting Hsueh, Jian Yu Hsieh, Yi Chun Huang, Tao Wang, Yen Hung Lin, Chih Ting Lin, Yao Joe Yang, Shey Shi Lu

Department of Electronic Engineering

National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 μ m CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor-α (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm²-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.

Original language	English
Article number	7386717
Pages (from-to)	790-800
Number of pages	11
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	9
Issue number	6
DOIs	https://doi.org/10.1109/TBCAS.2015.2507618
State	Published - 12 2015

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

Biosensor
CMOS
Rapid blood test
lab-on-a-chip
magnetic bead

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10.1109/TBCAS.2015.2507618

Cite this

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abstract = "A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 μ m CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor-α (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm2-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.",

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AU - Hsieh, Jian Yu

AU - Huang, Yi Chun

AU - Wang, Tao

AU - Lin, Yen Hung

AU - Lin, Chih Ting

AU - Yang, Yao Joe

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A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction

Abstract

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Keywords

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