A specific base transition occurs on replicating hepatitis delta virus RNA

Guangxiang Luo; Mei Chao; Sen Yung Hsieh; Camille Sureau; Kazuko Nishikura; John Taylor

A specific base transition occurs on replicating hepatitis delta virus RNA

Guangxiang Luo, Mei Chao, Sen Yung Hsieh, Camille Sureau, Kazuko Nishikura, John Taylor^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

224 Scopus citations

Abstract

Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

Original language	English
Pages (from-to)	1021-1027
Number of pages	7
Journal	Journal of Virology
Volume	64
Issue number	3
State	Published - 1990
Externally published	Yes

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title = "A specific base transition occurs on replicating hepatitis delta virus RNA",

abstract = "Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.",

author = "Guangxiang Luo and Mei Chao and Hsieh, {Sen Yung} and Camille Sureau and Kazuko Nishikura and John Taylor",

year = "1990",

language = "英语",

volume = "64",

pages = "1021--1027",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - A specific base transition occurs on replicating hepatitis delta virus RNA

AU - Luo, Guangxiang

AU - Chao, Mei

AU - Hsieh, Sen Yung

AU - Sureau, Camille

AU - Nishikura, Kazuko

AU - Taylor, John

PY - 1990

Y1 - 1990

N2 - Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

AB - Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

UR - http://www.scopus.com/inward/record.url?scp=0025255969&partnerID=8YFLogxK

M3 - 文章

C2 - 2304136

AN - SCOPUS:0025255969

SN - 0022-538X

VL - 64

SP - 1021

EP - 1027

JO - Journal of Virology

JF - Journal of Virology

IS - 3

ER -

A specific base transition occurs on replicating hepatitis delta virus RNA

Abstract

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