A successful live twin birth by in vitro fertilization after conservative treatment of recurrent endometrial cancer

Hsien Ming Wu, Chyong Huey Lai, Hong Yuan Huang, Hsin Shih Wang, Yung Kuei Soong*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

15 Scopus citations


Endometrial cancer is predominately a postmenopausal disease. Endometrial cancer in women of childbearing age is relatively unusual. Endometrial cancer is typically treated with hysterectomy. After the development of endometrial cancer, successful pregnancy is rare. We present a case of recurrent stage I endometrial adenocarcinoma in a 35-year-old woman. Magnetic resonance imaging (MRI) revealed endometrial lesions without myometrium invasion and no pelvic lymph node enlargement. The patient refused surgical intervention with abdominal hysterectomy and bilateral salpingo-oophorectomy because of her essential desire for children. Fertility-preserving medical therapy with megestrol acetate for 1 year and subsequent assisted reproductive treatment (ART) were performed. Successful pregnancy occurred after in vitro fertilization-embryo transfer (IVF-ET). On the basis of these observations and the low malignant potential of well-differentiated endometrial carcinoma, fertility-preserving treatment using Megace therapy was suggested. In this case, recurrence occurred after the completion of Megace therapy and three failed attempts at artificial insemination by the husband (AIH). Recurrent endometrial adenocarcinoma was documented using hysteroscopy and direct endometrial biopsy. Another course of Megace therapy was administered due to her desire for children. A successful pregnancy occurred after long-term medical treatment and IVF-ET.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalChang Gung Medical Journal
Issue number1
StatePublished - 01 2008


  • Endometrial adenocarcinoma
  • IVF
  • Megestrol acetate
  • Pregnancy
  • Recurrence


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