A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation

Shigeru Goto*, Takayuki Noguch, Yoshiki Morotomi, Roger Lord, John Board, Chao Long Chen, Bruno Jawan, Tair Long Pan, Yao Sen Chen, Toshiro Tatsuma, Seigo Kitano, Stephen V. Lynch

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 12-48 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.

Original languageEnglish
Pages (from-to)205-267
Number of pages63
JournalTransplant Immunology
Volume6
Issue number4
DOIs
StatePublished - 12 1998
Externally publishedYes

Fingerprint

Dive into the research topics of 'A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation'. Together they form a unique fingerprint.

Cite this