A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation

Shigeru Goto; Takayuki Noguch; Yoshiki Morotomi; Roger Lord; John Board; Chao Long Chen; Bruno Jawan; Tair Long Pan; Yao Sen Chen; Toshiro Tatsuma; Seigo Kitano; Stephen V. Lynch

doi:10.1016/s0966-3274(98)80017-8

A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation

Shigeru Goto^*
, Takayuki Noguch
, Yoshiki Morotomi
, Roger Lord
, John Board
, Chao Long Chen
, Bruno Jawan
, Tair Long Pan
, Yao Sen Chen
, Toshiro Tatsuma
, Seigo Kitano
, Stephen V. Lynch

^*Corresponding author for this work

University of Queensland
Chang Gung Memorial Hospital
Queensland Liver Transplant Service
Oita University

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 12-48 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.

Original language	English
Pages (from-to)	205-267
Number of pages	63
Journal	Transplant Immunology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/s0966-3274(98)80017-8
State	Published - 12 1998
Externally published	Yes

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title = "A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation",

abstract = "We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 12-48 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.",

author = "Shigeru Goto and Takayuki Noguch and Yoshiki Morotomi and Roger Lord and John Board and Chen, \{Chao Long\} and Bruno Jawan and Pan, \{Tair Long\} and Chen, \{Yao Sen\} and Toshiro Tatsuma and Seigo Kitano and Lynch, \{Stephen V.\}",

year = "1998",

month = dec,

doi = "10.1016/s0966-3274(98)80017-8",

language = "英语",

volume = "6",

pages = "205--267",

journal = "Transplant Immunology",

issn = "0966-3274",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation

AU - Goto, Shigeru

AU - Noguch, Takayuki

AU - Morotomi, Yoshiki

AU - Lord, Roger

AU - Board, John

AU - Chen, Chao Long

AU - Jawan, Bruno

AU - Pan, Tair Long

AU - Chen, Yao Sen

AU - Tatsuma, Toshiro

AU - Kitano, Seigo

AU - Lynch, Stephen V.

PY - 1998/12

Y1 - 1998/12

N2 - We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 12-48 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.

AB - We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 12-48 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.

UR - https://www.scopus.com/pages/publications/0032443503

U2 - 10.1016/s0966-3274(98)80017-8

DO - 10.1016/s0966-3274(98)80017-8

M3 - 文章

C2 - 10342741

AN - SCOPUS:0032443503

SN - 0966-3274

VL - 6

SP - 205

EP - 267

JO - Transplant Immunology

JF - Transplant Immunology

IS - 4

ER -

A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation

Abstract

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