Abstract
Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 346-347 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419048 |
| State | Published - 2022 |
| Externally published | Yes |
| Event | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: 23 10 2022 → 27 10 2022 |
Publication series
| Name | MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 |
|---|---|
| Country/Territory | China |
| City | Hybrid, Hangzhou |
| Period | 23/10/22 → 27/10/22 |
Bibliographical note
Publisher Copyright:© 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
Keywords
- 3D culture
- GelMA
- Immune cell
- Infiltration
- microfluidic platform
