A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY

Yu Chen Chen; Kang Yun Lee; Wei Lun Sun; Wan Chen Huang; Wei Chiao Chang; Cheng Hsien Liu

A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY

Yu Chen Chen
, Kang Yun Lee
, Wei Lun Sun
, Wan Chen Huang
, Wei Chiao Chang
, Cheng Hsien Liu^*

^*Corresponding author for this work

National Tsing Hua University
Taipei Medical University
Academia Sinica - Institute of Cellular and Organismic Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.

Original language	English
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	346-347
Number of pages	2
ISBN (Electronic)	9781733419048
State	Published - 2022
Externally published	Yes
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: 23 10 2022 → 27 10 2022

Publication series

Name	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	23/10/22 → 27/10/22

Bibliographical note

Publisher Copyright:
© 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3D culture
GelMA
Immune cell
Infiltration
microfluidic platform

Cite this

Chen, Y. C., Lee, K. Y., Sun, W. L., Huang, W. C., Chang, W. C., & Liu, C. H. (2022). A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 346-347). (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Chen, Yu Chen ; Lee, Kang Yun ; Sun, Wei Lun et al. / A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. pp. 346-347 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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title = "A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY",

abstract = "Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.",

keywords = "3D culture, GelMA, Immune cell, Infiltration, microfluidic platform",

author = "Chen, \{Yu Chen\} and Lee, \{Kang Yun\} and Sun, \{Wei Lun\} and Huang, \{Wan Chen\} and Chang, \{Wei Chiao\} and Liu, \{Cheng Hsien\}",

note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

year = "2022",

language = "英语",

series = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "346--347",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

}

Chen, YC, Lee, KY, Sun, WL, Huang, WC, Chang, WC & Liu, CH 2022, A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 346-347, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, Hybrid, Hangzhou, China, 23/10/22.

A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY. / Chen, Yu Chen; Lee, Kang Yun; Sun, Wei Lun et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 346-347 (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY

AU - Chen, Yu Chen

AU - Lee, Kang Yun

AU - Sun, Wei Lun

AU - Huang, Wan Chen

AU - Chang, Wei Chiao

AU - Liu, Cheng Hsien

PY - 2022

Y1 - 2022

N2 - Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.

AB - Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.

KW - 3D culture

KW - GelMA

KW - Immune cell

KW - Infiltration

KW - microfluidic platform

UR - https://www.scopus.com/pages/publications/85175736284

M3 - 会议稿件

AN - SCOPUS:85175736284

T3 - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 346

EP - 347

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

Chen YC, Lee KY, Sun WL, Huang WC, Chang WC, Liu CH. A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2022. p. 346-347. (MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

A TUMOR-ON-A-CHIP MICROFLUIDIC PLATFORM FOR IMMUNE CELL INFILTRATION STUDY

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Keywords

Other files and links

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Cite this