A voxel-based partial volume correction in nuclear medicine

Hsuan Ming Huang*, Ing Tsung Hsiao, Christian Wietholt, Ching Han Hsu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Most partial volume correction (PVC) methods are ROI-based, and assume uniform activity within each ROI. Here, we extended a PVC method, developed by Roussel et al (JNM, 1998) called geometric transfer matrix (GTM), to a voxel-based PVC approach called v-GTM which accounts non-uniform activity within each ROI. The v-GTM method was evaluated using simulated data (perfect co-registered MRIs). We investigated the influence of noise, the effect of compensating detector response during iterative reconstruction methods and the effect of non-uniform activity. For simulated data, noise did not affect the accuracy of v-GTM method seriously. When detector response compensation was applied in iterative reconstruction, both PVC methods did not improve the recovery values. In the non-uniform experiment, v-GTM had slightly better recovery values and less bias than those of GTM. Conclusion: v-GTM resulted better recovery values, and might be useful for PVC in small regions of interest.

Original languageEnglish
Title of host publicationMedical Imaging 2006
Subtitle of host publicationImage Processing
StatePublished - 2006
EventMedical Imaging 2006: Image Processing - San Diego, CA, United States
Duration: 13 02 200616 02 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6144 III
ISSN (Print)1605-7422


ConferenceMedical Imaging 2006: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA


  • Nuclear medicine
  • Partial Volume Correction
  • Restoration and deblurring


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