A voxel-based partial volume correction in nuclear medicine

Hsuan Ming Huang*, Ing Tsung Hsiao, Christian Wietholt, Ching Han Hsu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Most partial volume correction (PVC) methods are ROI-based, and assume uniform activity within each ROI. Here, we extended a PVC method, developed by Roussel et al (JNM, 1998) called geometric transfer matrix (GTM), to a voxel-based PVC approach called v-GTM which accounts non-uniform activity within each ROI. The v-GTM method was evaluated using simulated data (perfect co-registered MRIs). We investigated the influence of noise, the effect of compensating detector response during iterative reconstruction methods and the effect of non-uniform activity. For simulated data, noise did not affect the accuracy of v-GTM method seriously. When detector response compensation was applied in iterative reconstruction, both PVC methods did not improve the recovery values. In the non-uniform experiment, v-GTM had slightly better recovery values and less bias than those of GTM. Conclusion: v-GTM resulted better recovery values, and might be useful for PVC in small regions of interest.

Original languageEnglish
Title of host publicationMedical Imaging 2006
Subtitle of host publicationImage Processing
DOIs
StatePublished - 2006
EventMedical Imaging 2006: Image Processing - San Diego, CA, United States
Duration: 13 02 200616 02 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6144 III
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2006: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA
Period13/02/0616/02/06

Keywords

  • Nuclear medicine
  • Partial Volume Correction
  • Restoration and deblurring

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