TY - JOUR
T1 - Absence of Epstein-Barr virus infection in squamous cell carcinoma of upper urinary tract and urinary bladder
AU - Ng, Kwai Fong
AU - Chuang, Cheng Keng
AU - Chang, Phei Lang
AU - Chu, Sheng Hsien
AU - Wallace, Christopher Glenn
AU - Chen, Tse Ching
PY - 2006/10
Y1 - 2006/10
N2 - Objectives: To address whether Epstein-Barr virus (EBV) infection may be involved in the carcinogenesis of squamous cell carcinoma of the upper urinary tract and urinary bladder (SCC-UB). EBV has been implicated in the genesis of a variety of human cancers, including urothelial carcinoma of the urinary bladder. Methods: Whether EBV infection is related to SCC-UB carcinogenesis was investigated by in situ hybridization for EBV-encoded RNA and immunohistochemistry for latent membrane protein-1 in 26 cases of SCC-UB. Results: EBV-encoded RNA and latent membrane protein-1 were identified in the control case of nasopharyngeal carcinoma. None of the SCC-UB cases had a nuclear signal of EBV-encoded RNA, and the cancer cells, normal urothelial cells, and inflammatory cells were all negative for latent membrane protein-1, irrespective of the site of SCC-UB. Conclusions: This study is the first to explore the role of EBV infection in SCC-UB. Our results suggest that EBV infection is not involved in the carcinogenesis of SCC of the renal pelvis, ureter, and urinary bladder.
AB - Objectives: To address whether Epstein-Barr virus (EBV) infection may be involved in the carcinogenesis of squamous cell carcinoma of the upper urinary tract and urinary bladder (SCC-UB). EBV has been implicated in the genesis of a variety of human cancers, including urothelial carcinoma of the urinary bladder. Methods: Whether EBV infection is related to SCC-UB carcinogenesis was investigated by in situ hybridization for EBV-encoded RNA and immunohistochemistry for latent membrane protein-1 in 26 cases of SCC-UB. Results: EBV-encoded RNA and latent membrane protein-1 were identified in the control case of nasopharyngeal carcinoma. None of the SCC-UB cases had a nuclear signal of EBV-encoded RNA, and the cancer cells, normal urothelial cells, and inflammatory cells were all negative for latent membrane protein-1, irrespective of the site of SCC-UB. Conclusions: This study is the first to explore the role of EBV infection in SCC-UB. Our results suggest that EBV infection is not involved in the carcinogenesis of SCC of the renal pelvis, ureter, and urinary bladder.
UR - http://www.scopus.com/inward/record.url?scp=33750297676&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2006.05.023
DO - 10.1016/j.urology.2006.05.023
M3 - 文章
C2 - 17070351
AN - SCOPUS:33750297676
SN - 0090-4295
VL - 68
SP - 775
EP - 777
JO - Urology
JF - Urology
IS - 4
ER -
