Absence of precore stop mutant in chronic dual (B And C) and triple (B, C, and D) hepatitis virus infection

Chau Ting Yeh, Cheng Tang Chiu, Sun Lung Tsai, Shiu Tsan Hong, Chia Ming Chu, Yun Fan Liaw*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

21 Scopus citations

Abstract

Sequences of hepatitis B virus (HBV) precore regions from 7 patients with HBV and hepatitis C virus (HCV) dual infection and 2 with HBV, HCV, and hepatitis D virus (HDV) triple infection were analyzed. Two patients, 1 with only acute HBV infection and 1 with only chronic HBV infection, were also included for comparison. All patients had antibodies against HBV e antigen (anti-HBe) except 1 with chronic hepatitis Band C. No precore stop mutation at codon 28 (TGG to TAG mutation) was found in 21 cloned sequences from the 7 patients with HBV and HCV infection, nor in 11 cloned sequences from 2 patients with HBV, HCV, and HDV infection. However, mutations in other positions of the precore region were observed in 2 patients with hepatitis Band C. In both cases, precore sequences with mutations in different positions were obtained from the same serum sample. No mutations were observed in other positions of the precore region in the 2 patients with hepatitis B, C, and D. The presence of anti-HBe in these patients was probably due to the low level of HBV replication and not to the presence of the precore stop mutant.

Original languageEnglish
Pages (from-to)1582-1585
Number of pages4
JournalJournal of Infectious Diseases
Volume170
Issue number6
DOIs
StatePublished - 12 1994
Externally publishedYes

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