TY - JOUR
T1 - Absence of precore stop mutant in chronic dual (B And C) and triple (B, C, and D) hepatitis virus infection
AU - Yeh, Chau Ting
AU - Chiu, Cheng Tang
AU - Tsai, Sun Lung
AU - Hong, Shiu Tsan
AU - Chu, Chia Ming
AU - Liaw, Yun Fan
PY - 1994/12
Y1 - 1994/12
N2 - Sequences of hepatitis B virus (HBV) precore regions from 7 patients with HBV and hepatitis C virus (HCV) dual infection and 2 with HBV, HCV, and hepatitis D virus (HDV) triple infection were analyzed. Two patients, 1 with only acute HBV infection and 1 with only chronic HBV infection, were also included for comparison. All patients had antibodies against HBV e antigen (anti-HBe) except 1 with chronic hepatitis Band C. No precore stop mutation at codon 28 (TGG to TAG mutation) was found in 21 cloned sequences from the 7 patients with HBV and HCV infection, nor in 11 cloned sequences from 2 patients with HBV, HCV, and HDV infection. However, mutations in other positions of the precore region were observed in 2 patients with hepatitis Band C. In both cases, precore sequences with mutations in different positions were obtained from the same serum sample. No mutations were observed in other positions of the precore region in the 2 patients with hepatitis B, C, and D. The presence of anti-HBe in these patients was probably due to the low level of HBV replication and not to the presence of the precore stop mutant.
AB - Sequences of hepatitis B virus (HBV) precore regions from 7 patients with HBV and hepatitis C virus (HCV) dual infection and 2 with HBV, HCV, and hepatitis D virus (HDV) triple infection were analyzed. Two patients, 1 with only acute HBV infection and 1 with only chronic HBV infection, were also included for comparison. All patients had antibodies against HBV e antigen (anti-HBe) except 1 with chronic hepatitis Band C. No precore stop mutation at codon 28 (TGG to TAG mutation) was found in 21 cloned sequences from the 7 patients with HBV and HCV infection, nor in 11 cloned sequences from 2 patients with HBV, HCV, and HDV infection. However, mutations in other positions of the precore region were observed in 2 patients with hepatitis Band C. In both cases, precore sequences with mutations in different positions were obtained from the same serum sample. No mutations were observed in other positions of the precore region in the 2 patients with hepatitis B, C, and D. The presence of anti-HBe in these patients was probably due to the low level of HBV replication and not to the presence of the precore stop mutant.
UR - http://www.scopus.com/inward/record.url?scp=0028007341&partnerID=8YFLogxK
U2 - 10.1093/infdis/170.6.1582
DO - 10.1093/infdis/170.6.1582
M3 - 文章
C2 - 7995999
AN - SCOPUS:0028007341
SN - 0022-1899
VL - 170
SP - 1582
EP - 1585
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -