A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients

Y. J. Lin, L. Wan, J. J.C. Sheu, C. M. Huang, C. W. Lin, Y. C. Lan, C. H. Lai, C. H. Hung, Y. Tsai, C. H. Tsai, T. H. Lin, C. P. Chen, Fuu Jen Tsai*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalLupus
Volume17
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • Interleukin-18
  • Single nucleotide polymorphism
  • Systemic lupus erythematosus

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