Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: Effects of prostaglandin F2α

Chin Shaw Stella Tsai; Shue Fen Luo; Chung Chu Ning; Chien Liang Lin; Ming Chung Jiang; Ching Fong Liao

doi:10.1016/j.biopha.2008.07.094

Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: Effects of prostaglandin F₂α

Chin Shaw Stella Tsai
, Shue Fen Luo
, Chung Chu Ning
, Chien Liang Lin
, Ming Chung Jiang^*
, Ching Fong Liao

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Epidemiological studies indicate that acetylsalicylic acid may reduce the risk of mortality due to colon cancers. Metastasis is the major cause of cancer death. Matrix metalloproteinases (MMPs) play important roles in tumor invasion regulation, and prostaglandin F₂α (PGF₂α) is a key stimulator of MMP production. Thus, we investigated whether acetylsalicylic acid regulated MMP activity and the invasion of cancer cells and whether PGF₂α attenuated acetylsalicylic acid-inhibited invasion of cancer cells. Gelatin-based zymography assays showed that acetylsalicylic acid inhibited the MMP-2 activity of B16F0 melanoma cells. Matrigel-based chemoinvasion assays showed that acetylsalicylic acid inhibited the invasion of B16F0 cells. Acetylsalicylic acid can inhibit PGF₂α synthesis and PGF₂α is a key stimulator of MMP-2 production. Our data showed that PGF₂α treatment attenuated the acetylsalicylic acid-inhibited invasion of B16F0 cells. In animal experiments, acetylsalicylic acid reduced colorectal metastasis of B16F0 cells in C57BL/6J mice by 44%. Our results suggest that PGF₂α is a therapeutic target for metastasis inhibition and acetylsalicylic acid may possess anti-metastasis ability.

Original language	English
Pages (from-to)	522-527
Number of pages	6
Journal	Biomedicine and Pharmacotherapy
Volume	63
Issue number	7
DOIs	https://doi.org/10.1016/j.biopha.2008.07.094
State	Published - 08 2009
Externally published	Yes

Keywords

Acetylsalicylic acid
MMP-2
PGFα

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biopha.2008.07.094

Cite this

@article{4c4e3719d1a84b388e0ec071dec7ee30,

title = "Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: Effects of prostaglandin F2α",

abstract = "Epidemiological studies indicate that acetylsalicylic acid may reduce the risk of mortality due to colon cancers. Metastasis is the major cause of cancer death. Matrix metalloproteinases (MMPs) play important roles in tumor invasion regulation, and prostaglandin F2α (PGF2α) is a key stimulator of MMP production. Thus, we investigated whether acetylsalicylic acid regulated MMP activity and the invasion of cancer cells and whether PGF2α attenuated acetylsalicylic acid-inhibited invasion of cancer cells. Gelatin-based zymography assays showed that acetylsalicylic acid inhibited the MMP-2 activity of B16F0 melanoma cells. Matrigel-based chemoinvasion assays showed that acetylsalicylic acid inhibited the invasion of B16F0 cells. Acetylsalicylic acid can inhibit PGF2α synthesis and PGF2α is a key stimulator of MMP-2 production. Our data showed that PGF2α treatment attenuated the acetylsalicylic acid-inhibited invasion of B16F0 cells. In animal experiments, acetylsalicylic acid reduced colorectal metastasis of B16F0 cells in C57BL/6J mice by 44\%. Our results suggest that PGF2α is a therapeutic target for metastasis inhibition and acetylsalicylic acid may possess anti-metastasis ability.",

keywords = "Acetylsalicylic acid, MMP-2, PGFα",

author = "\{Stella Tsai\}, \{Chin Shaw\} and Luo, \{Shue Fen\} and Ning, \{Chung Chu\} and Lin, \{Chien Liang\} and Jiang, \{Ming Chung\} and Liao, \{Ching Fong\}",

year = "2009",

month = aug,

doi = "10.1016/j.biopha.2008.07.094",

language = "英语",

volume = "63",

pages = "522--527",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

publisher = "Elsevier Masson s.r.l.",

number = "7",

}

Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: Effects of prostaglandin F₂α. / Stella Tsai, Chin Shaw; Luo, Shue Fen; Ning, Chung Chu et al.
In: Biomedicine and Pharmacotherapy, Vol. 63, No. 7, 08.2009, p. 522-527.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice

T2 - Effects of prostaglandin F2α

AU - Stella Tsai, Chin Shaw

AU - Luo, Shue Fen

AU - Ning, Chung Chu

AU - Lin, Chien Liang

AU - Jiang, Ming Chung

AU - Liao, Ching Fong

PY - 2009/8

Y1 - 2009/8

N2 - Epidemiological studies indicate that acetylsalicylic acid may reduce the risk of mortality due to colon cancers. Metastasis is the major cause of cancer death. Matrix metalloproteinases (MMPs) play important roles in tumor invasion regulation, and prostaglandin F2α (PGF2α) is a key stimulator of MMP production. Thus, we investigated whether acetylsalicylic acid regulated MMP activity and the invasion of cancer cells and whether PGF2α attenuated acetylsalicylic acid-inhibited invasion of cancer cells. Gelatin-based zymography assays showed that acetylsalicylic acid inhibited the MMP-2 activity of B16F0 melanoma cells. Matrigel-based chemoinvasion assays showed that acetylsalicylic acid inhibited the invasion of B16F0 cells. Acetylsalicylic acid can inhibit PGF2α synthesis and PGF2α is a key stimulator of MMP-2 production. Our data showed that PGF2α treatment attenuated the acetylsalicylic acid-inhibited invasion of B16F0 cells. In animal experiments, acetylsalicylic acid reduced colorectal metastasis of B16F0 cells in C57BL/6J mice by 44%. Our results suggest that PGF2α is a therapeutic target for metastasis inhibition and acetylsalicylic acid may possess anti-metastasis ability.

AB - Epidemiological studies indicate that acetylsalicylic acid may reduce the risk of mortality due to colon cancers. Metastasis is the major cause of cancer death. Matrix metalloproteinases (MMPs) play important roles in tumor invasion regulation, and prostaglandin F2α (PGF2α) is a key stimulator of MMP production. Thus, we investigated whether acetylsalicylic acid regulated MMP activity and the invasion of cancer cells and whether PGF2α attenuated acetylsalicylic acid-inhibited invasion of cancer cells. Gelatin-based zymography assays showed that acetylsalicylic acid inhibited the MMP-2 activity of B16F0 melanoma cells. Matrigel-based chemoinvasion assays showed that acetylsalicylic acid inhibited the invasion of B16F0 cells. Acetylsalicylic acid can inhibit PGF2α synthesis and PGF2α is a key stimulator of MMP-2 production. Our data showed that PGF2α treatment attenuated the acetylsalicylic acid-inhibited invasion of B16F0 cells. In animal experiments, acetylsalicylic acid reduced colorectal metastasis of B16F0 cells in C57BL/6J mice by 44%. Our results suggest that PGF2α is a therapeutic target for metastasis inhibition and acetylsalicylic acid may possess anti-metastasis ability.

KW - Acetylsalicylic acid

KW - MMP-2

KW - PGFα

UR - https://www.scopus.com/pages/publications/68149178461

U2 - 10.1016/j.biopha.2008.07.094

DO - 10.1016/j.biopha.2008.07.094

M3 - 文章

C2 - 18849138

AN - SCOPUS:68149178461

SN - 0753-3322

VL - 63

SP - 522

EP - 527

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

IS - 7

ER -