Acquired hyponatremia in pediatric living donor liver transplantation

Sheng Chun Yang, Chih Hsien Wang, Chao Long Chen, Kwok Wai Cheng, Shao Chun Wu, Tsung Hsiao Shih, Bruno Jawan, Chia Jung Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations


Background: The aim of this study was to evaluate the incidence of acquired hyponatremia (AH) in our pediatric living donor liver transplantation (LDLT) patients, and to identify the potential predictive risk factors of the causes of AH.

Material/Methods: The 189 pediatric LDLT patients were divided into 2 groups: serum sodium level at the end of the surgery lower than 130 mEq/L in GI (n=16) and higher than 130 mEq/L in GII (n=173). Patients’ data were analyzed by Mann-Whitney U test, univariate analysis, and multiple binary logistic regression model. The Hosmer-Lemeshow goodness-of-fit test was used to evaluate the logistic model formulated. P value <0.05 was regarded as statistically significant.

Results: In the multiple binary logistic regression model, the hypotonic solution administration rate (ml/kg/h) was the only independent predictor of AH with a p<0.017. Receiver operating curve (ROC) analysis indicated that giving more than 3.5 ml/kg/h hypotonic solution infusion may cause AH. Preoperative hyponatremia did not increase the incidence of acquired hyponatremia.

Conclusions: Increasing the administration of hypotonic solution by 1 ml/kg/h in pediatric LDLT would increase the risk of developing AH by 1.272 times. The critical administration rate of hypotonic solution was 3.5 ml/kg/h.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalAnnals of Transplantation
Issue number1
StatePublished - 24 11 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Ann Transplant, 2014.


  • Anesthesia
  • Hyponatremia
  • Liver Transplantation
  • Living Donors
  • Pediatrics


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