Activin a predicts left ventricular remodeling and mortality in patients with ST-Elevation myocardial infarction

Jeng Feng Lin, Shun Yi Hsu, Ming Sheng Teng, Semon Wu, Chien An Hsieh, Shih Jung Jang, Chih Jen Liu, Hsuan Li Huang, Yu Lin Ko*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations

Abstract

Background: Activin A levels increase in a variety of heart diseases including ST-elevation myocardial infarction (STEMI). The aim of this study is to investigate whether the level of activin A can be beneficial in predicting left ventricular remodeling, heart failure, and death in patients with ST-elevation myocardial infarction (STEMI). Methods:We enrolled 278 patients with STEMIwho had their activin A levels measured on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Thereafter, the clinical events of these patients were followed for a maximum of 3 years, including all-cause death and readmission for heart failure. Results: During hospitalization, higher activin A level was associated with higher triglyceride level, lower left ventricular ejection fraction (LVEF), and lower left ventricular end diastolic ventricular volume index (LVEDVI) in multivariable linear regression model. During follow-up, patients with activin A levels > 129 pg/ml had significantly lower LVEF, and higher LVEDVI at 6 months. Kaplan-Meier survival curves showed that activin A level > 129 pg/ml was a predictor of all-cause death (p = 0.022), but not a predictor of heart failure (p = 0.767). Conclusions: Activin A level > 129 pg/ml predicts worse left ventricular remodeling and all-cause death in STEMI.

Original languageEnglish
Pages (from-to)420-427
Number of pages8
JournalActa Cardiologica Sinica
Volume32
Issue number4
DOIs
StatePublished - 07 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016, Republic of China Society of Cardiology. All rights reserved.

Keywords

  • Activin A
  • Acute myocardial infarction
  • Left ventricular remodeling

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