Abstract
Background: Activin A levels increase in a variety of heart diseases including ST-elevation myocardial infarction (STEMI). The aim of this study is to investigate whether the level of activin A can be beneficial in predicting left ventricular remodeling, heart failure, and death in patients with ST-elevation myocardial infarction (STEMI). Methods:We enrolled 278 patients with STEMIwho had their activin A levels measured on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Thereafter, the clinical events of these patients were followed for a maximum of 3 years, including all-cause death and readmission for heart failure. Results: During hospitalization, higher activin A level was associated with higher triglyceride level, lower left ventricular ejection fraction (LVEF), and lower left ventricular end diastolic ventricular volume index (LVEDVI) in multivariable linear regression model. During follow-up, patients with activin A levels > 129 pg/ml had significantly lower LVEF, and higher LVEDVI at 6 months. Kaplan-Meier survival curves showed that activin A level > 129 pg/ml was a predictor of all-cause death (p = 0.022), but not a predictor of heart failure (p = 0.767). Conclusions: Activin A level > 129 pg/ml predicts worse left ventricular remodeling and all-cause death in STEMI.
Original language | English |
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Pages (from-to) | 420-427 |
Number of pages | 8 |
Journal | Acta Cardiologica Sinica |
Volume | 32 |
Issue number | 4 |
DOIs | |
State | Published - 07 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016, Republic of China Society of Cardiology. All rights reserved.
Keywords
- Activin A
- Acute myocardial infarction
- Left ventricular remodeling