Acute hydrocephalus upregulates monoamine oxidase mRNA in neonatal rat brain

Meng Fai Kuo; Kwan Dun Wu; Ruei Meei Wu; Yong Kwang Tu; Huei Shyong Wang

doi:10.1097/00001756-200408260-00028

Acute hydrocephalus upregulates monoamine oxidase mRNA in neonatal rat brain

Meng Fai Kuo, Kwan Dun Wu, Ruei Meei Wu, Yong Kwang Tu, Huei Shyong Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Metabolic derangement of the dopamine system in hydrocephalic brain has been observed, but the change of monoamine oxidase (MAO), the major enzyme to metabolize dopamine, is not known. The metabolic changes of dopamine and MAO mRNA in the striaturn were examined in acute hydrocephalic rats whose ventricular size and intracranial pressure were controlled to a similar degree. The tissue levels of dopamine and its metabolites as well as MAO-A and MAO-B mRNA elevated significantly in hydrocephalus. Cerebrospinal fluid (CSF) diversion reversed these changes and induced an initial decline, followed by an elevation of these substances in extracellular fluid. In summary, the metabolism of dopamine system in the striatum was up-regulated in acute hydrocephalus and CSF diversion reversed this metabolic derangement.

Original language	English
Pages (from-to)	1975-1978
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	12
DOIs	https://doi.org/10.1097/00001756-200408260-00028
State	Published - 26 08 2004
Externally published	Yes

Keywords

Corpus striatum
Dopamine
Hydrocephalus
Monoamine oxidase
mRNA

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10.1097/00001756-200408260-00028

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title = "Acute hydrocephalus upregulates monoamine oxidase mRNA in neonatal rat brain",

abstract = "Metabolic derangement of the dopamine system in hydrocephalic brain has been observed, but the change of monoamine oxidase (MAO), the major enzyme to metabolize dopamine, is not known. The metabolic changes of dopamine and MAO mRNA in the striaturn were examined in acute hydrocephalic rats whose ventricular size and intracranial pressure were controlled to a similar degree. The tissue levels of dopamine and its metabolites as well as MAO-A and MAO-B mRNA elevated significantly in hydrocephalus. Cerebrospinal fluid (CSF) diversion reversed these changes and induced an initial decline, followed by an elevation of these substances in extracellular fluid. In summary, the metabolism of dopamine system in the striatum was up-regulated in acute hydrocephalus and CSF diversion reversed this metabolic derangement.",

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AU - Kuo, Meng Fai

AU - Wu, Kwan Dun

AU - Wu, Ruei Meei

AU - Tu, Yong Kwang

AU - Wang, Huei Shyong

PY - 2004/8/26

Y1 - 2004/8/26

N2 - Metabolic derangement of the dopamine system in hydrocephalic brain has been observed, but the change of monoamine oxidase (MAO), the major enzyme to metabolize dopamine, is not known. The metabolic changes of dopamine and MAO mRNA in the striaturn were examined in acute hydrocephalic rats whose ventricular size and intracranial pressure were controlled to a similar degree. The tissue levels of dopamine and its metabolites as well as MAO-A and MAO-B mRNA elevated significantly in hydrocephalus. Cerebrospinal fluid (CSF) diversion reversed these changes and induced an initial decline, followed by an elevation of these substances in extracellular fluid. In summary, the metabolism of dopamine system in the striatum was up-regulated in acute hydrocephalus and CSF diversion reversed this metabolic derangement.

AB - Metabolic derangement of the dopamine system in hydrocephalic brain has been observed, but the change of monoamine oxidase (MAO), the major enzyme to metabolize dopamine, is not known. The metabolic changes of dopamine and MAO mRNA in the striaturn were examined in acute hydrocephalic rats whose ventricular size and intracranial pressure were controlled to a similar degree. The tissue levels of dopamine and its metabolites as well as MAO-A and MAO-B mRNA elevated significantly in hydrocephalus. Cerebrospinal fluid (CSF) diversion reversed these changes and induced an initial decline, followed by an elevation of these substances in extracellular fluid. In summary, the metabolism of dopamine system in the striatum was up-regulated in acute hydrocephalus and CSF diversion reversed this metabolic derangement.

KW - Corpus striatum

KW - Dopamine

KW - Hydrocephalus

KW - Monoamine oxidase

KW - mRNA

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Acute hydrocephalus upregulates monoamine oxidase mRNA in neonatal rat brain

Abstract

Keywords

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