Acute kidney injury in patients with pulmonary embolism: A population-based cohort study

Chih Hsiang Chang; Chung Ming Fu; Pei Chun Fan; Shao Wei Chen; Su Wei Chang; Chun Tai Mao; Ya Chung Tian; Yung Chang Chen; Pao-Hsien Chu; Tien Hsing Chen

doi:10.1097/MD.0000000000005822

Acute kidney injury in patients with pulmonary embolism: A population-based cohort study

Chih Hsiang Chang, Chung Ming Fu, Pei Chun Fan, Shao Wei Chen, Su Wei Chang, Chun Tai Mao, Ya Chung Tian, Yung Chang Chen, Pao-Hsien Chu, Tien Hsing Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Acute kidney injury (AKI) is overlooked in patients with pulmonary embolism (PE). Risk factors for and long-term outcomes of this complication remain unknown. This study evaluated the predictors and prognosis of AKI in patients with PE. This retrospective cohort study used Taiwan's National Health Insurance Research Database. We enrolled a total of 7588 patients who were admitted to a hospital for PE from January1997 to December 2011 and administered anticoagulation or thrombolytic agents. All demographic data, risk factors, and outcomes were analyzed. AKI was diagnosed in 372 (4.9%) patients. Multivariate logistic regression analysis revealed pre-existing chronic kidney disease, hypertension, diabetes mellitus, massive PE, anemia, and sepsis as independent risk factors for AKI. In the long-term follow-up, the survival rate was similar in the AKI and non-AKI groups. Careful risk factor screening and intensive intervention in patients with AKI might yield outcomes similar to those in patients without AKI.

Original language	English
Article number	e5822
Journal	Medicine (United States)
Volume	96
Issue number	9
DOIs	https://doi.org/10.1097/MD.0000000000005822
State	Published - 01 03 2017

Bibliographical note

Publisher Copyright:
Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.

Keywords

acute kidney injury
database
prognosis
pulmonary embolism
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MD.0000000000005822

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title = "Acute kidney injury in patients with pulmonary embolism: A population-based cohort study",

abstract = "Acute kidney injury (AKI) is overlooked in patients with pulmonary embolism (PE). Risk factors for and long-term outcomes of this complication remain unknown. This study evaluated the predictors and prognosis of AKI in patients with PE. This retrospective cohort study used Taiwan's National Health Insurance Research Database. We enrolled a total of 7588 patients who were admitted to a hospital for PE from January1997 to December 2011 and administered anticoagulation or thrombolytic agents. All demographic data, risk factors, and outcomes were analyzed. AKI was diagnosed in 372 (4.9%) patients. Multivariate logistic regression analysis revealed pre-existing chronic kidney disease, hypertension, diabetes mellitus, massive PE, anemia, and sepsis as independent risk factors for AKI. In the long-term follow-up, the survival rate was similar in the AKI and non-AKI groups. Careful risk factor screening and intensive intervention in patients with AKI might yield outcomes similar to those in patients without AKI.",

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AU - Chang, Chih Hsiang

AU - Fu, Chung Ming

AU - Fan, Pei Chun

AU - Chen, Shao Wei

AU - Chang, Su Wei

AU - Mao, Chun Tai

AU - Tian, Ya Chung

AU - Chen, Yung Chang

AU - Chu, Pao-Hsien

AU - Chen, Tien Hsing

PY - 2017/3/1

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N2 - Acute kidney injury (AKI) is overlooked in patients with pulmonary embolism (PE). Risk factors for and long-term outcomes of this complication remain unknown. This study evaluated the predictors and prognosis of AKI in patients with PE. This retrospective cohort study used Taiwan's National Health Insurance Research Database. We enrolled a total of 7588 patients who were admitted to a hospital for PE from January1997 to December 2011 and administered anticoagulation or thrombolytic agents. All demographic data, risk factors, and outcomes were analyzed. AKI was diagnosed in 372 (4.9%) patients. Multivariate logistic regression analysis revealed pre-existing chronic kidney disease, hypertension, diabetes mellitus, massive PE, anemia, and sepsis as independent risk factors for AKI. In the long-term follow-up, the survival rate was similar in the AKI and non-AKI groups. Careful risk factor screening and intensive intervention in patients with AKI might yield outcomes similar to those in patients without AKI.

AB - Acute kidney injury (AKI) is overlooked in patients with pulmonary embolism (PE). Risk factors for and long-term outcomes of this complication remain unknown. This study evaluated the predictors and prognosis of AKI in patients with PE. This retrospective cohort study used Taiwan's National Health Insurance Research Database. We enrolled a total of 7588 patients who were admitted to a hospital for PE from January1997 to December 2011 and administered anticoagulation or thrombolytic agents. All demographic data, risk factors, and outcomes were analyzed. AKI was diagnosed in 372 (4.9%) patients. Multivariate logistic regression analysis revealed pre-existing chronic kidney disease, hypertension, diabetes mellitus, massive PE, anemia, and sepsis as independent risk factors for AKI. In the long-term follow-up, the survival rate was similar in the AKI and non-AKI groups. Careful risk factor screening and intensive intervention in patients with AKI might yield outcomes similar to those in patients without AKI.

KW - acute kidney injury

KW - database

KW - prognosis

KW - pulmonary embolism

KW - risk factors

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ER -

Acute kidney injury in patients with pulmonary embolism: A population-based cohort study

Abstract

Bibliographical note

Keywords

UN SDGs

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