Acute myeloid leukemia associated with acute myocardial infarction and dural sinus thrombosis: The possible role of leukemia-related hyperhomocysteinemia

Hung Chang; Tung Liang Lin; Wan Jing Ho; Lung An Hsu

doi:10.1016/S1726-4901(08)70093-5

Acute myeloid leukemia associated with acute myocardial infarction and dural sinus thrombosis: The possible role of leukemia-related hyperhomocysteinemia

Hung Chang, Tung Liang Lin^*, Wan Jing Ho, Lung An Hsu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

The association of acute myeloid leukemia (AML) and acute myocardial infarction (AMI) is rare. We encountered a 40-year-old female with inferior wall myocardial infarction that occurred simultaneously with the diagnosis of AML. She developed subsequent dural sinus thrombosis during chemotherapy for AML. The screen for thrombophilia revealed that she had hyperhomocysteinemia. In the English literature, only 4 cases have been reported previously. Remission induction was not affected by the occurrence of AMI, although anthracyclines were avoided in all cases. In the absence of conventional risk factors for coronary artery disease, AMI can be related to leukemia per se and the role of homocysteine is worth further investigation.

Original language	English
Pages (from-to)	416-420
Number of pages	5
Journal	Journal of the Chinese Medical Association
Volume	71
Issue number	8
DOIs	https://doi.org/10.1016/S1726-4901(08)70093-5
State	Published - 08 2008
Externally published	Yes

Keywords

Acute myeloid leukemia
Acute myocardial infarction
Dural sinus thrombosis
Homocysteine
Thrombophilia

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10.1016/S1726-4901(08)70093-5

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title = "Acute myeloid leukemia associated with acute myocardial infarction and dural sinus thrombosis: The possible role of leukemia-related hyperhomocysteinemia",

abstract = "The association of acute myeloid leukemia (AML) and acute myocardial infarction (AMI) is rare. We encountered a 40-year-old female with inferior wall myocardial infarction that occurred simultaneously with the diagnosis of AML. She developed subsequent dural sinus thrombosis during chemotherapy for AML. The screen for thrombophilia revealed that she had hyperhomocysteinemia. In the English literature, only 4 cases have been reported previously. Remission induction was not affected by the occurrence of AMI, although anthracyclines were avoided in all cases. In the absence of conventional risk factors for coronary artery disease, AMI can be related to leukemia per se and the role of homocysteine is worth further investigation.",

keywords = "Acute myeloid leukemia, Acute myocardial infarction, Dural sinus thrombosis, Homocysteine, Thrombophilia",

author = "Hung Chang and Lin, {Tung Liang} and Ho, {Wan Jing} and Hsu, {Lung An}",

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T1 - Acute myeloid leukemia associated with acute myocardial infarction and dural sinus thrombosis

T2 - The possible role of leukemia-related hyperhomocysteinemia

AU - Chang, Hung

AU - Lin, Tung Liang

AU - Ho, Wan Jing

AU - Hsu, Lung An

PY - 2008/8

Y1 - 2008/8

N2 - The association of acute myeloid leukemia (AML) and acute myocardial infarction (AMI) is rare. We encountered a 40-year-old female with inferior wall myocardial infarction that occurred simultaneously with the diagnosis of AML. She developed subsequent dural sinus thrombosis during chemotherapy for AML. The screen for thrombophilia revealed that she had hyperhomocysteinemia. In the English literature, only 4 cases have been reported previously. Remission induction was not affected by the occurrence of AMI, although anthracyclines were avoided in all cases. In the absence of conventional risk factors for coronary artery disease, AMI can be related to leukemia per se and the role of homocysteine is worth further investigation.

AB - The association of acute myeloid leukemia (AML) and acute myocardial infarction (AMI) is rare. We encountered a 40-year-old female with inferior wall myocardial infarction that occurred simultaneously with the diagnosis of AML. She developed subsequent dural sinus thrombosis during chemotherapy for AML. The screen for thrombophilia revealed that she had hyperhomocysteinemia. In the English literature, only 4 cases have been reported previously. Remission induction was not affected by the occurrence of AMI, although anthracyclines were avoided in all cases. In the absence of conventional risk factors for coronary artery disease, AMI can be related to leukemia per se and the role of homocysteine is worth further investigation.

KW - Acute myeloid leukemia

KW - Acute myocardial infarction

KW - Dural sinus thrombosis

KW - Homocysteine

KW - Thrombophilia

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Acute myeloid leukemia associated with acute myocardial infarction and dural sinus thrombosis: The possible role of leukemia-related hyperhomocysteinemia

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