TY - JOUR
T1 - Acute respiratory distress syndrome caused by leukemic infiltration of the lung
AU - Wu, Yao Kuang
AU - Huang, Yi Chih
AU - Huang, Shiu Feng
AU - Huang, Chung Chi
AU - Tsai, Ying Huang
PY - 2008/5
Y1 - 2008/5
N2 - Respiratory distress syndrome resulting from leukemic pulmonary infiltrates is seldom diagnosed antemortem. Two 60- and 80-year-old women presented with general malaise, progressive shortness of breath, and hyperleukocytosis, which progressed to acute respiratory distress syndrome (ARDS) after admission. Acute leukemia with pulmonary infection was initially diagnosed, but subsequent examinations including open lung biopsy revealed leukemic pulmonary infiltrates without infection. In one case, the clinical condition and chest radiography improved initially after combination therapy with chemotherapy for leukemia and aggressive pulmonary support. However, new pulmonary infiltration on chest radiography and hypoxemia recurred, which was consistent with acute lysis pneumopathy. Despite aggressive treatment, both patients died due to rapidly deteriorating condition. Leukemic pulmonary involvement should be considered in acute leukemia patients with non-infectious diffusive lung infiltration, especially in acute leukemia with a high blast count.
AB - Respiratory distress syndrome resulting from leukemic pulmonary infiltrates is seldom diagnosed antemortem. Two 60- and 80-year-old women presented with general malaise, progressive shortness of breath, and hyperleukocytosis, which progressed to acute respiratory distress syndrome (ARDS) after admission. Acute leukemia with pulmonary infection was initially diagnosed, but subsequent examinations including open lung biopsy revealed leukemic pulmonary infiltrates without infection. In one case, the clinical condition and chest radiography improved initially after combination therapy with chemotherapy for leukemia and aggressive pulmonary support. However, new pulmonary infiltration on chest radiography and hypoxemia recurred, which was consistent with acute lysis pneumopathy. Despite aggressive treatment, both patients died due to rapidly deteriorating condition. Leukemic pulmonary involvement should be considered in acute leukemia patients with non-infectious diffusive lung infiltration, especially in acute leukemia with a high blast count.
KW - Acute lysis pneumopathy
KW - Acute respiratory distress syndrome
KW - Leukemia
KW - Leukemic infiltration
UR - http://www.scopus.com/inward/record.url?scp=44949140656&partnerID=8YFLogxK
U2 - 10.1016/S0929-6646(08)60108-4
DO - 10.1016/S0929-6646(08)60108-4
M3 - 文章
C2 - 18492627
AN - SCOPUS:44949140656
SN - 0929-6646
VL - 107
SP - 419
EP - 423
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 5
ER -