Acute sodium chlorite poisoning associated with renal failure

Ja Liang Lin*, Paik Seong Lim

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


A 25-year-old Chinese male presented with generalized cyanosis and respiratory distress. The patient was known to have ingested 10 g of sodium chlorite in a suicide attempt. Methemoglobinemia was found and intravenous methylene blue was given repeatedly. However, the therapy could not prevent an acute hemolytic crisis. Methemoglobinemia remained profound (43.1% and disseminated intravascular coagulation ensued. He was put on CAVHD to correct the fluid overload and probably to remove the active metabolites of the chlorite. After 24 h, the methemoglobin was reduced to 16.9% However, the development of acute renal failure further complicated the clinical course. Percutaneous renal biopsy suggested a picture of acute tubulointerstitial nephropathy. In addition, hemodialysis was continued for 4 weeks. After 3 months, renal function normalized. To our knowledge, there has been no clinical report of human intoxication with sodium chlorite.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalRenal Failure
Issue number5
StatePublished - 1993
Externally publishedYes


  • Acute renal failure
  • Methemoglobinemia
  • Sodium chlorite


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