Adhesion/growth-regulatory galectins: Insights into their ligand selectivity using natural glycoproteins and glycotopes

Albert M. Wu*, Tanuja Singh, Jia Hau Liu, Sabine André, Martin Lensch, Hans Christian Siebert, Mickael Krzeminski, Alexandre M.J.J. Bonvin, Herbert Kaltner, June H. Wu, Hans Joachim Gabius

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Scopus citations

Abstract

"Biochemistry text books commonly make it appear that it is a foregone conclusion that the hardware of biological information storage and transfer is confined to nucleotides and amino acids, the letters of the genetic code. However, the remarkable talents of a third class of biomolecules are often overlooked" [1]. This statement from a recent review guides the readers to look at and fully appreciate the chemical/lectinochemical characteristics of carbohydrates that underlie the concept of the sugar code [2].

Original languageEnglish
Title of host publicationThe Molecular Immunology of Complex Carbohydrates-3
EditorsAlbert Wu
Pages117-141
Number of pages25
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume705
ISSN (Print)0065-2598

Keywords

  • Agglutinin
  • Docking
  • Glycosylation
  • Lectin phylogeny
  • Sugar code

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